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Laura Sanders

Laura Sanders

3 years ago

Xenobots, tiny living machines, can duplicate themselves.

Strange and complex behavior of frog cell blobs


A xenobot “parent,” shaped like a hungry Pac-Man (shown in red false color), created an “offspring” xenobot (green sphere) by gathering loose frog cells in its opening.

Tiny “living machines” made of frog cells can make copies of themselves. This newly discovered renewal mechanism may help create self-renewing biological machines.

According to Kirstin Petersen, an electrical and computer engineer at Cornell University who studies groups of robots, “this is an extremely exciting breakthrough.” She says self-replicating robots are a big step toward human-free systems.

Researchers described the behavior of xenobots earlier this year (SN: 3/31/21). Small clumps of skin stem cells from frog embryos knitted themselves into small spheres and started moving. Cilia, or cellular extensions, powered the xenobots around their lab dishes.

The findings are published in the Proceedings of the National Academy of Sciences on Dec. 7. The xenobots can gather loose frog cells into spheres, which then form xenobots.
The researchers call this type of movement-induced reproduction kinematic self-replication. The study's coauthor, Douglas Blackiston of Tufts University in Medford, Massachusetts, and Harvard University, says this is typical. For example, sexual reproduction requires parental sperm and egg cells. Sometimes cells split or budded off from a parent.

“This is unique,” Blackiston says. These xenobots “find loose parts in the environment and cobble them together.” This second generation of xenobots can move like their parents, Blackiston says.
The researchers discovered that spheroid xenobots could only produce one more generation before dying out. The original xenobots' shape was predicted by an artificial intelligence program, allowing for four generations of replication.

A C shape, like an openmouthed Pac-Man, was predicted to be a more efficient progenitor. When improved xenobots were let loose in a dish, they began scooping up loose cells into their gaping “mouths,” forming more sphere-shaped bots (see image below). As many as 50 cells clumped together in the opening of a parent to form a mobile offspring. A xenobot is made up of 4,000–6,000 frog cells.

Petersen likes the Xenobots' small size. “The fact that they were able to do this at such a small scale just makes it even better,” she says. Miniature xenobots could sculpt tissues for implantation or deliver therapeutics inside the body.

Beyond the xenobots' potential jobs, the research advances an important science, says study coauthor and Tufts developmental biologist Michael Levin. The science of anticipating and controlling the outcomes of complex systems, he says.

“No one could have predicted this,” Levin says. “They regularly surprise us.” Researchers can use xenobots to test the unexpected. “This is about advancing the science of being less surprised,” Levin says.

More on Science

Michael Hunter, MD

Michael Hunter, MD

2 years ago

5 Drugs That May Increase Your Risk of Dementia

Photo by danilo.alvesd on Unsplash

While our genes can't be changed easily, you can avoid some dementia risk factors. Today we discuss dementia and five drugs that may increase risk.

Memory loss appears to come with age, but we're not talking about forgetfulness. Sometimes losing your car keys isn't an indication of dementia. Dementia impairs the capacity to think, remember, or make judgments. Dementia hinders daily tasks.

Alzheimers is the most common dementia. Dementia is not normal aging, unlike forgetfulness. Aging increases the risk of Alzheimer's and other dementias. A family history of the illness increases your risk, according to the Mayo Clinic (USA).

Given that our genes are difficult to change (I won't get into epigenetics), what are some avoidable dementia risk factors? Certain drugs may cause cognitive deterioration.

Today we look at four drugs that may cause cognitive decline.

Dementia and benzodiazepines

Benzodiazepine sedatives increase brain GABA levels. Example benzodiazepines:

  • Diazepam (Valium) (Valium)

  • Alprazolam (Xanax) (Xanax)

  • Clonazepam (Klonopin) (Klonopin)

Addiction and overdose are benzodiazepine risks. Yes! These medications don't raise dementia risk.

USC study: Benzodiazepines don't increase dementia risk in older adults.

Benzodiazepines can produce short- and long-term amnesia. This memory loss hinders memory formation. Extreme cases can permanently impair learning and memory. Anterograde amnesia is uncommon.

2. Statins and dementia

Statins reduce cholesterol. They prevent a cholesterol-making chemical. Examples:

  • Atorvastatin (Lipitor) (Lipitor)

  • Fluvastatin (Lescol XL) (Lescol XL)

  • Lovastatin (Altoprev) (Altoprev)

  • Pitavastatin (Livalo, Zypitamag) (Livalo, Zypitamag)

  • Pravastatin (Pravachol) (Pravachol)

  • Rosuvastatin (Crestor, Ezallor) (Crestor, Ezallor)

  • Simvastatin (Zocor) (Zocor)

Photo by Towfiqu barbhuiya on Unsplash

This finding is contentious. Harvard's Brigham and Womens Hospital's Dr. Joann Manson says:

“I think that the relationship between statins and cognitive function remains controversial. There’s still not a clear conclusion whether they help to prevent dementia or Alzheimer’s disease, have neutral effects, or increase risk.”

This one's off the dementia list.

3. Dementia and anticholinergic drugs

Anticholinergic drugs treat many conditions, including urine incontinence. Drugs inhibit acetylcholine (a brain chemical that helps send messages between cells). Acetylcholine blockers cause drowsiness, disorientation, and memory loss.

First-generation antihistamines, tricyclic antidepressants, and overactive bladder antimuscarinics are common anticholinergics among the elderly.

Anticholinergic drugs may cause dementia. One study found that taking anticholinergics for three years or more increased the risk of dementia by 1.54 times compared to three months or less. After stopping the medicine, the danger may continue.

4. Drugs for Parkinson's disease and dementia

Cleveland Clinic (USA) on Parkinson's:

Parkinson's disease causes age-related brain degeneration. It causes delayed movements, tremors, and balance issues. Some are inherited, but most are unknown. There are various treatment options, but no cure.

Parkinson's medications can cause memory loss, confusion, delusions, and obsessive behaviors. The drug's effects on dopamine cause these issues.

A 2019 JAMA Internal Medicine study found powerful anticholinergic medications enhance dementia risk.

Those who took anticholinergics had a 1.5 times higher chance of dementia. Individuals taking antidepressants, antipsychotic drugs, anti-Parkinson’s drugs, overactive bladder drugs, and anti-epileptic drugs had the greatest risk of dementia.

Anticholinergic medicines can lessen Parkinson's-related tremors, but they slow cognitive ability. Anticholinergics can cause disorientation and hallucinations in those over 70.

Photo by Wengang Zhai on Unsplash

5. Antiepileptic drugs and dementia

The risk of dementia from anti-seizure drugs varies with drugs. Levetiracetam (Keppra) improves Alzheimer's cognition.

One study linked different anti-seizure medications to dementia. Anti-epileptic medicines increased the risk of Alzheimer's disease by 1.15 times in the Finnish sample and 1.3 times in the German population. Depakote, Topamax are drugs.

Tomas Pueyo

Tomas Pueyo

2 years ago

Soon, a Starship Will Transform Humanity

SpaceX's Starship.

Source

Launched last week.

Four minutes in:

SpaceX will succeed. When it does, its massiveness will matter.

Source

Its payload will revolutionize space economics.

Civilization will shift.

We don't yet understand how this will affect space and Earth culture. Grab it.

The Cost of Space Transportation Has Decreased Exponentially

Space launches have increased dramatically in recent years.

We mostly send items to LEO, the green area below:

I always had a hard time remembering that LEO stands for Low-Earth Orbit. Now I imagine a lion orbiting the Earth, and that did the trick.

SpaceX's reusable rockets can send these things to LEO. Each may launch dozens of payloads into space.

With all these launches, we're sending more than simply things to space. Volume and mass. Since the 1980s, launching a kilogram of payload to LEO has become cheaper:

Falcon Heavy is the heavy rocket from SpaceX. Notice this is a logarithmic scale! The Falcon Heavy was SpaceX’s biggest rocket yet. It will soon be superseded by Starship.

One kilogram in a large rocket cost over $75,000 in the 1980s. Carrying one astronaut cost nearly $5M! Falcon Heavy's $1,500/kg price is 50 times lower. SpaceX's larger, reusable rockets are amazing.

SpaceX's Starship rocket will continue. It can carry over 100 tons to LEO, 50% more than the current Falcon heavy. Thousands of launches per year. Elon Musk predicts Falcon Heavy's $1,500/kg cost will plummet to $100 in 23 years.

In context:

Angara was the rocket that previously held the record for cheapest transportation to LEO.

People underestimate this.

2. The Benefits of Affordable Transportation

Compare Earth's transportation costs:

Source: US Department of Transportation.

It's no surprise that the US and Northern Europe are the wealthiest and have the most navigable interior waterways.

The Mississippi River is one of the biggest systems of navigable waterways on Earth. And on top of that, navigation along the US’s Mexican Gulf and East Coast is protected by a series of islands, making sea shipping easier than in the open ocean.European navigable waterways

So what? since sea transportation is cheaper than land. Inland waterways are even better than sea transportation since weather is less of an issue, currents can be controlled, and rivers serve two banks instead of one for coastal transportation.

In France, because population density follows river systems, rivers are valuable. Cheap transportation brought people and money to rivers, especially their confluences.

Look at the population. Can you see dark red lines? Those are people living close to rivers. You can guess where the rivers are by looking at the map. Also, you can see the bigger cities are always at the confluence between rivers.

How come? Why were humans surrounding rivers?

Imagine selling meat for $10 per kilogram. Transporting one kg one kilometer costs $1. Your margin decreases $1 each kilometer. You can only ship 10 kilometers. For example, you can only trade with four cities:

If instead, your cost of transportation is half, what happens? It costs you $0.5 per km. You now have higher margins with each city you traded with. More importantly, you can reach 20-km markets.

However, 2x distance 4x surface! You can now trade with sixteen cities instead of four! Metcalfe's law states that a network's value increases with its nodes squared. Since now sixteen cities can connect to yours. Each city now has sixteen connections! They get affluent and can afford more meat.

Rivers lower travel costs, connecting many cities, which can trade more, get wealthy, and buy more.

The right network is worth at least an order of magnitude more than the left! The cheaper the transport, the more trade at a lower cost, the more income generated, the more that wealth can be reinvested in better canals, bridges, and roads, and the wealth grows even more.

Throughout history. Rome was established around cheap Mediterranean transit and preoccupied with cutting overland transportation costs with their famous roadways. Communications restricted their empire.

This map shows the distance from Rome in terms of days of travel. The size of the Roman Empire was about five weeks of travel. This is not a coincidence. Source: Orbis, the Stanford Geospatial Network Model of the Roman World

The Egyptians lived around the Nile, the Vikings around the North Sea, early Japan around the Seto Inland Sea, and China started canals in the 5th century BC.

Transportation costs shaped empires.Starship is lowering new-world transit expenses. What's possible?

3. Change Organizations, Change Companies, Change the World

Starship is a conveyor belt to LEO. A new world of opportunity opens up as transportation prices drop 100x in a decade.

Satellite engineers have spent decades shedding milligrams. Weight influenced every decision: pricing structure, volumes to be sent, material selections, power sources, thermal protection, guiding, navigation, and control software. Weight was everything in the mission. To pack as much science into every millimeter, NASA missions had to be miniaturized. Engineers were indoctrinated against mass.

No way.

Starship is not constrained by any space mission, robotic or crewed.

Starship obliterates the mass constraint and every last vestige of cultural baggage it has gouged into the minds of spacecraft designers. A dollar spent on mass optimization no longer buys a dollar saved on launch cost. It buys nothing. It is time to raise the scope of our ambition and think much bigger. — Casey Handmer, Starship is still not understood

A Tesla Roadster in space makes more sense.

Starman, the roadster, and the Earth. Source.

It went beyond bad PR. It told the industry: Did you care about every microgram? No more. My rockets are big enough to send a Tesla without noticing. Industry watchers should have noticed.

Most didn’t. Artemis is a global mission to send astronauts to the Moon and build a base. Artemis uses disposable Space Launch System rockets. Instead of sending two or three dinky 10-ton crew habitats over the next decade, Starship might deliver 100x as much cargo and create a base for 1,000 astronauts in a year or two. Why not? Because Artemis remains in a pre-Starship paradigm where each kilogram costs a million dollars and we must aggressively descope our objective.

An overengineer at work

Space agencies can deliver 100x more payload to space for the same budget with 100x lower costs and 100x higher transportation volumes. How can space economy saturate this new supply?

Before Starship, NASA supplied heavy equipment for Moon base construction. After Starship, Caterpillar and Deere may space-qualify their products with little alterations. Instead than waiting decades for NASA engineers to catch up, we could send people to build a space outpost with John Deere equipment in a few years.

History is littered with the wreckage of former industrial titans that underestimated the impact of new technology and overestimated their ability to adapt: Blockbuster, Motorola, Kodak, Nokia, RIM, Xerox, Yahoo, IBM, Atari, Sears, Hitachi, Polaroid, Toshiba, HP, Palm, Sony, PanAm, Sega, Netscape, Compaq, GM… — Casey Handmer, Starship is still not understood

Everyone saw it coming, but senior management failed to realize that adaption would involve moving beyond their established business practice. Others will if they don't.

4. The Starship Possibilities

It's Starlink.

SpaceX invented affordable cargo space and grasped its implications first. How can we use all this inexpensive cargo nobody knows how to use?

Satellite communications seemed like the best way to capitalize on it. They tried. Starlink, designed by SpaceX, provides fast, dependable Internet worldwide. Beaming information down is often cheaper than cable. Already profitable.

Starlink is one use for all this cheap cargo space. Many more. The longer firms ignore the opportunity, the more SpaceX will acquire.

What are these chances?

Satellite imagery is outdated and lacks detail. We can improve greatly. Synthetic aperture radar can take beautiful shots like this:

This radar image acquired by the SIR-C/X-SAR radar on board the Space Shuttle Endeavour shows the Teide volcano. The city of Santa Cruz de Tenerife is visible as the purple and white area on the lower right edge of the island. Lava flows at the summit crater appear in shades of green and brown, while vegetation zones appear as areas of purple, green and yellow on the volcano’s flanks. Source.

Have you ever used Google Maps and thought, "I want to see this in more detail"? What if I could view Earth live? What if we could livestream an infrared image of Earth?

The fall of Kabul. Source: Maxar

We could launch hundreds of satellites with such mind-blowing visual precision of the Earth that we would dramatically improve the accuracy of our meteorological models; our agriculture; where crime is happening; where poachers are operating in the savannah; climate change; and who is moving military personnel where. Is that useful?

What if we could see Earth in real time? That affects businesses? That changes society?

Nojus Tumenas

Nojus Tumenas

2 years ago

NASA: Strange Betelgeuse Explosion Just Took Place

Orion's red supergiant Betelgeuse erupted. This is astronomers' most magnificent occurrence.

Betelgeuse, a supergiant star in Orion, garnered attention in 2019 for its peculiar appearance. It continued to dim in 2020.

The star was previously thought to explode as a supernova. Studying the event has revealed what happened to Betelgeuse since it happened.

Astronomers saw that the star released a large amount of material, causing it to lose a section of its surface.

They have never seen anything like this and are unsure what caused the star to release so much material.

According to Harvard-Smithsonian Center for Astrophysics astrophysicist Andrea Dupre, astronomers' data reveals an unexplained mystery.

They say it's a new technique to examine star evolution. The James Webb telescope revealed the star's surface features.

Corona flares are stellar mass ejections. These eruptions change the Sun's outer atmosphere.

This could affect power grids and satellite communications if it hits Earth.

Betelgeuse's flare ejected four times more material than the Sun's corona flare.

Astronomers have monitored star rhythms for 50 years. They've seen its dimming and brightening cycle start, stop, and repeat.

Monitoring Betelgeuse's pulse revealed the eruption's power.

Dupre believes the star's convection cells are still amplifying the blast's effects, comparing it to an imbalanced washing machine tub.

The star's outer layer has returned to normal, Hubble data shows. The photosphere slowly rebuilds its springy surface.

Dupre noted the star's unusual behavior. For instance, it’s causing its interior to bounce.

This suggests that the mass ejections that caused the star's surface to lose mass were two separate processes.

Researchers hope to better understand star mass ejection with the James Webb Space Telescope.

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Vivek Singh

Vivek Singh

3 years ago

A Warm Welcome to Web3 and the Future of the Internet

Let's take a look back at the internet's history and see where we're going — and why.

Tim Berners Lee had a problem. He was at CERN, the world's largest particle physics factory, at the time. The institute's stated goal was to study the simplest particles with the most sophisticated scientific instruments. The institute completed the LEP Tunnel in 1988, a 27 kilometer ring. This was Europe's largest civil engineering project (to study smaller particles — electrons).

The problem Tim Berners Lee found was information loss, not particle physics. CERN employed a thousand people in 1989. Due to team size and complexity, people often struggled to recall past project information. While these obstacles could be overcome, high turnover was nearly impossible. Berners Lee addressed the issue in a proposal titled ‘Information Management'.

When a typical stay is two years, data is constantly lost. The introduction of new people takes a lot of time from them and others before they understand what is going on. An emergency situation may require a detective investigation to recover technical details of past projects. Often, the data is recorded but cannot be found. — Information Management: A Proposal

He had an idea. Create an information management system that allowed users to access data in a decentralized manner using a new technology called ‘hypertext'.
To quote Berners Lee, his proposal was “vague but exciting...”. The paper eventually evolved into the internet we know today. Here are three popular W3C standards used by billions of people today:


(credit: CERN)

HTML (Hypertext Markup)

A web formatting language.

URI (Unique Resource Identifier)

Each web resource has its own “address”. Known as ‘a URL'.

HTTP (Hypertext Transfer Protocol)

Retrieves linked resources from across the web.

These technologies underpin all computer work. They were the seeds of our quest to reorganize information, a task as fruitful as particle physics.

Tim Berners-Lee would probably think the three decades from 1989 to 2018 were eventful. He'd be amazed by the billions, the inspiring, the novel. Unlocking innovation at CERN through ‘Information Management'.
The fictional character would probably need a drink, walk, and a few deep breaths to fully grasp the internet's impact. He'd be surprised to see a few big names in the mix.

Then he'd say, "Something's wrong here."

We should review the web's history before going there. Was it a success after Berners Lee made it public? Web1 and Web2: What is it about what we are doing now that so many believe we need a new one, web3?

Per Outlier Ventures' Jamie Burke:

Web 1.0 was read-only.
Web 2.0 was the writable
Web 3.0 is a direct-write web.

Let's explore.

Web1: The Read-Only Web

Web1 was the digital age. We put our books, research, and lives ‘online'. The web made information retrieval easier than any filing cabinet ever. Massive amounts of data were stored online. Encyclopedias, medical records, and entire libraries were put away into floppy disks and hard drives.

In 2015, the web had around 305,500,000,000 pages of content (280 million copies of Atlas Shrugged).

Initially, one didn't expect to contribute much to this database. Web1 was an online version of the real world, but not yet a new way of using the invention.

One gets the impression that the web has been underutilized by historians if all we can say about it is that it has become a giant global fax machine. — Daniel Cohen, The Web's Second Decade (2004)

That doesn't mean developers weren't building. The web was being advanced by great minds. Web2 was born as technology advanced.

Web2: Read-Write Web

Remember when you clicked something on a website and the whole page refreshed? Is it too early to call the mid-2000s ‘the good old days'?
Browsers improved gradually, then suddenly. AJAX calls augmented CGI scripts, and applications began sending data back and forth without disrupting the entire web page. One button to ‘digg' a post (see below). Web experiences blossomed.

In 2006, Digg was the most active ‘Web 2.0' site. (Photo: Ethereum Foundation Taylor Gerring)

Interaction was the focus of new applications. Posting, upvoting, hearting, pinning, tweeting, liking, commenting, and clapping became a lexicon of their own. It exploded in 2004. Easy ways to ‘write' on the internet grew, and continue to grow.

Facebook became a Web2 icon, where users created trillions of rows of data. Google and Amazon moved from Web1 to Web2 by better understanding users and building products and services that met their needs.

Business models based on Software-as-a-Service and then managing consumer data within them for a fee have exploded.

Web2 Emerging Issues

Unbelievably, an intriguing dilemma arose. When creating this read-write web, a non-trivial question skirted underneath the covers. Who owns it all?

You have no control over [Web 2] online SaaS. People didn't realize this because SaaS was so new. People have realized this is the real issue in recent years.

Even if these organizations have good intentions, their incentive is not on the users' side.
“You are not their customer, therefore you are their product,” they say. With Laura Shin, Vitalik Buterin, Unchained

A good plot line emerges. Many amazing, world-changing software products quietly lost users' data control.
For example: Facebook owns much of your social graph data. Even if you hate Facebook, you can't leave without giving up that data. There is no ‘export' or ‘exit'. The platform owns ownership.

While many companies can pull data on you, you cannot do so.

On the surface, this isn't an issue. These companies use my data better than I do! A complex group of stakeholders, each with their own goals. One is maximizing shareholder value for public companies. Tim Berners-Lee (and others) dislike the incentives created.

“Show me the incentive and I will show you the outcome.” — Berkshire Hathaway's CEO

It's easy to see what the read-write web has allowed in retrospect. We've been given the keys to create content instead of just consume it. On Facebook and Twitter, anyone with a laptop and internet can participate. But the engagement isn't ours. Platforms own themselves.

Web3: The ‘Unmediated’ Read-Write Web

Tim Berners Lee proposed a decade ago that ‘linked data' could solve the internet's data problem.

However, until recently, the same principles that allowed the Web of documents to thrive were not applied to data...

The Web of Data also allows for new domain-specific applications. Unlike Web 2.0 mashups, Linked Data applications work with an unbound global data space. As new data sources appear on the Web, they can provide more complete answers.

At around the same time as linked data research began, Satoshi Nakamoto created Bitcoin. After ten years, it appears that Berners Lee's ideas ‘link' spiritually with cryptocurrencies.

What should Web 3 do?

Here are some quick predictions for the web's future.

Users' data:
Users own information and provide it to corporations, businesses, or services that will benefit them.

Defying censorship:

No government, company, or institution should control your access to information (1, 2, 3)

Connect users and platforms:

Create symbiotic rather than competitive relationships between users and platform creators.

Open networks:

“First, the cryptonetwork-participant contract is enforced in open source code. Their voices and exits are used to keep them in check.” Dixon, Chris (4)

Global interactivity:

Transacting value, information, or assets with anyone with internet access, anywhere, at low cost

Self-determination:

Giving you the ability to own, see, and understand your entire digital identity.

Not pull, push:

‘Push' your data to trusted sources instead of ‘pulling' it from others.

Where Does This Leave Us?

Change incentives, change the world. Nick Babalola

People believe web3 can help build a better, fairer system. This is not the same as equal pay or outcomes, but more equal opportunity.

It should be noted that some of these advantages have been discussed previously. Will the changes work? Will they make a difference? These unanswered questions are technical, economic, political, and philosophical. Unintended consequences are likely.

We hope Web3 is a more democratic web. And we think incentives help the user. If there’s one thing that’s on our side, it’s that open has always beaten closed, given a long enough timescale.

We are at the start. 

Trevor Stark

Trevor Stark

2 years ago

Peter Thiels's Multi-Billion Dollar Net Worth's Unknown Philosopher

Peter Thiel studied philosophy as an undergraduate.

Peter Thiel and Elon Musk, Co-Founders of PayPal

Peter Thiel has $7.36 billion.

Peter is a world-ranked chess player, has a legal degree, and has written profitable novels.

In 1999, he co-founded PayPal with Max Levchin, which merged with X.com.

Peter Thiel made $55 million after selling the company to eBay for $1.5 billion in 2002.

You may be wondering…

How did Peter turn $55 million into his now multi-billion dollar net worth?

One amazing investment?

Facebook.

Thiel was Facebook's first external investor. He bought 10% of the company for $500,000 in 2004.

This investment returned 159% annually, 200x in 8 years.

By 2012, Thiel sold almost all his Facebook shares, becoming a billionaire.

What was the investment thesis of Peter?

This investment appeared ridiculous. Facebook was an innovative startup.

Thiel's $500,000 contribution transformed Facebook.

Screenshot of Facebook in 2004 (Source)

Harvard students have access to Facebook's 8 features and 1 photo per profile.

How did Peter determine that this would be a wise investment, then?

Facebook is a mimetic desire machine.

Social media's popularity is odd. Why peek at strangers' images on a computer?

Peter Thiel studied under French thinker Rene Girard at Stanford.

Mimetic Desire explains social media's success.

Mimetic Desire is the idea that humans desire things simply because other people do.

If nobody wanted it, would you?

Would you desire a family, a luxury car, or expensive clothes if no one else did? Girard says no.

People we admire affect our aspirations because we're social animals. Every person has a role model.

Our nonreligious culture implies role models are increasingly other humans, not God.

The idea explains why social media influencers are so powerful.

Why would Andrew Tate or Kim Kardashian matter if people weren't mimetic?

Humanity is fundamentally motivated by social comparison.

Facebook takes advantage of this need for social comparison, and puts it on a global scale.

It aggregates photographs and updates from millions of individuals.

Facebook mobile allows 24/7 social comparison.

Thiel studied mimetic desire with Girard and realized Facebook exploits the urge for social comparison to gain money.

Social media is more significant and influential than ever, despite Facebook's decline.

Thiel and Girard show that applied philosophy (particularly in business) can be immensely profitable.

John Rampton

John Rampton

2 years ago

Ideas for Samples of Retirement Letters

Ready to quit full-time? No worries.

Baby Boomer retirement has accelerated since COVID-19 began. In 2020, 29 million boomers retire. Over 3 million more than in 2019. 75 million Baby Boomers will retire by 2030.

First, quit your work to enjoy retirement. Leave a professional legacy. Your retirement will start well. It all starts with a retirement letter.

Retirement Letter

Retirement letters are formal resignation letters. Different from other resignation letters, these don't tell your employer you're leaving. Instead, you're quitting.

Since you're not departing over grievances or for a better position or higher income, you may usually terminate the relationship amicably. Consulting opportunities are possible.

Thank your employer for their support and give them transition information.

Resignation letters aren't merely a formality. This method handles wages, insurance, and retirement benefits.

Retirement letters often accompany verbal notices to managers. Schedule a meeting before submitting your retirement letter to discuss your plans. The letter will be stored alongside your start date, salary, and benefits in your employee file.

Retirement is typically well-planned. Employers want 6-12 months' notice.

Summary

  • Guidelines for Giving Retirement Notice

  • Components of a Successful Retirement Letter

  • Template for Retirement Letter

  • Ideas for Samples of Retirement Letters

  • First Example of Retirement Letter

  • Second Example of Retirement Letter

  • Third Example of Retirement Letter

  • Fourth Example of Retirement Letter

  • Fifth Example of Retirement Letter

  • Sixth Example of Retirement Letter

  • Seventh Example of Retirement Letter

  • Eighth Example of Retirement Letter

  • Ninth Example of Retirement Letter

  • Tenth Example of Retirement Letter

  • Frequently Asked Questions

  • 1. What is a letter of retirement?

  • 2. Why should you include a letter of retirement?

  • 3. What information ought to be in your retirement letter?

  • 4. Must I provide notice?

  • 5. What is the ideal retirement age?

Guidelines for Giving Retirement Notice

While starting a new phase, you're also leaving a job you were qualified for. You have years of experience. So, it may not be easy to fill a retirement-related vacancy.

Talk to your boss in person before sending a letter. Notice is always appreciated. Properly announcing your retirement helps you and your organization transition.

How to announce retirement:

  • Learn about the retirement perks and policies offered by the company. The first step in figuring out whether you're eligible for retirement benefits is to research your company's retirement policy.

  • Don't depart without providing adequate notice. You should give the business plenty of time to replace you if you want to retire in a few months.

  • Help the transition by offering aid. You could be a useful resource if your replacement needs training.

  • Contact the appropriate parties. The original copy should go to your boss. Give a copy to HR because they will manage your 401(k), pension, and health insurance.

  • Investigate the option of working as a consultant or part-time. If you desire, you can continue doing some limited work for the business.

  • Be nice to others. Describe your achievements and appreciation. Additionally, express your gratitude for giving you the chance to work with such excellent coworkers.

  • Make a plan for your future move. Simply updating your employer on your goals will help you maintain a good working relationship.

  • Use a formal letter or email to formalize your plans. The initial step is to speak with your supervisor and HR in person, but you must also give written notice.

Components of a Successful Retirement Letter

To write a good retirement letter, keep in mind the following:

  • A formal salutation. Here, the voice should be deliberate, succinct, and authoritative.

  • Be specific about your intentions. The key idea of your retirement letter is resignation. Your decision to depart at this time should be reflected in your letter. Remember that your intention must be clear-cut.

  • Your deadline. This information must be in resignation letters. Laws and corporate policies may both stipulate a minimum amount of notice.

  • A kind voice. Your retirement letter shouldn't contain any resentments, insults, or other unpleasantness. Your letter should be a model of professionalism and grace. A straightforward thank you is a terrific approach to accomplish that.

  • Your ultimate goal. Chaos may start to happen as soon as you turn in your resignation letter. Your position will need to be filled. Additionally, you will have to perform your obligations up until a successor is found. Your availability during the interim period should be stated in your resignation letter.

  • Give us a way to reach you. Even if you aren't consulting, your company will probably get in touch with you at some point. They might send you tax documents and details on perks. By giving your contact information, you can make this process easier.

Template for Retirement Letter

Identify

Title you held

Address

Supervisor's name

Supervisor’s position

Company name

HQ address

Date

[SUPERVISOR],

1.

Inform that you're retiring. Include your last day worked.

2.

Employer thanks. Mention what you're thankful for. Describe your accomplishments and successes.

3.

Helping moves things ahead. Plan your retirement. Mention your consultancy interest.

Sincerely,

[Signature]

First and last name

Phone number

Personal Email

Ideas for Samples of Retirement Letters

First Example of Retirement Letter

Martin D. Carey

123 Fleming St

Bloomfield, New Jersey 07003

(555) 555-1234

June 6th, 2022

Willie E. Coyote

President

Acme Co

321 Anvil Ave

Fairfield, New Jersey 07004

Dear Mr. Coyote,

This letter notifies Acme Co. of my retirement on August 31, 2022.

There has been no other organization that has given me that sense of belonging and purpose.

My fifteen years at the helm of the Structural Design Division have given me‌ ‌a‌ ‌strong sense‌ ‌of‌ ‌purpose. I’ve been fortunate to have your support, and I’ll be always grateful for the opportunity you offered me.

I had a difficult time making this decision. ‌As a result of finding a small property in Arizona where we will be able to spend our remaining days together, my wife and I have decided to officially retire.

In spite of my regret at being unable to contribute to the firm we’ve built, I believe it is wise to move on.

My heart will always belong to Acme Co. ‌Thank you for the opportunity and best of luck in the years to come.

Sincerely,

Martin D. Carey

Second Example of Retirement Letter

Gustavo Fring

Los Pollas Hermanos

12000–12100 Coors Rd SW,

Albuquerque, New Mexico 87045

Dear Mr. Fring,

I write this letter to announce my formal retirement from Los Pollas Hermanos as manager, effective October 15.

As an employee at Los Pollas Hermanos, I appreciate all the great opportunities you have given me. ‌It has been a pleasure to work with and learn from my colleagues for the past 10 years, and I am looking forward to my next challenge.

If there is anything I can do to assist during this time, please let me know.

Sincerely,

Linda T. Crespo

Third Example of Retirement Letter

William M. Arviso

4387 Parkview Drive

Tustin, CA 92680

May 2, 2023

Tony Stark

Owner

Stark Industries

200 Industrial Avenue

Long Beach, CA 90803

Dear Tony:

I’m writing to inform you that my final day of work at Stark Industries will be May14, 2023. ‌When that time comes, I intend‌ ‌to‌ ‌retire.

As I embark on this new chapter in my life, I would like to thank you and the entire Stark Industries team for providing me with so many opportunities. ‌You have all been a pleasure to work with and I will miss you all when I retire.

I am glad to assist you with the transition in any way I can to ensure your new hire has a seamless experience. ‌All ongoing projects will be completed until my retirement date, and all key information will be handed over‌ ‌to‌ ‌the‌ ‌team.

Once again, thank you for the opportunity to be part of the Stark Industries team. ‌All the best to you and the team in the days to come.

Please do not hesitate to contact me if you require any additional information. ‌In order to finalize my retirement plans, I’ll meet with HR and can provide any details that may be necessary.

Sincerely,

(Signature)

William M. Arviso

Fourth Example of Retirement Letter

Garcia, Barbara

First Street, 5432

New York City, NY 10001

(1234) (555) 123–1234

1 October 2022

Gunther

Owner

Central Perk

199 Lafayette St.

New York City, NY 10001

Mr. Gunther,

The day has finally arrived. ‌As I never imagined, I will be formally retiring from Central Perk on November 1st, 2022.

Considering how satisfied I am with my current position, this may surprise you. ‌It would be best if I retired now since my health has deteriorated, so I think this is a good time to do so.

There is no doubt that the past‌ ‌two‌ ‌decades‌ ‌have‌ ‌been‌ ‌wonderful. ‌Over the years, I have seen a small coffee shop grow into one of the city’s top‌ ‌destinations.

It will be hard for me to leave this firm without wondering what more success we could have achieved. But I’m confident that you and the rest of the Central Perk team will achieve great things.

My family and I will never forget what you’ve done for us, and I am grateful for the chance you’ve given me. My house is always open to you.

Sincerely Yours

Garcia, Barbara

Fifth Example of Retirement Letter

Pat Williams

618 Spooky Place

Monstropolis, 23221

123–555–0031

pwilliams@email.com

Feb. 16, 2022

Mike Wazowski

Co-CEO

Monters, Inc.

324 Scare Road

Monstropolis

Dear Mr. Wazowski,

As a formal notice of my upcoming retirement, I am submitting this letter. ‌I will be leaving Monters, Inc. on‌ ‌April‌ ‌13.

These past 10 years as a marketing associate have provided me with many opportunities. ‌Since we started our company a decade ago, we have seen the face of harnessing screams change dramatically into harnessing laughter. ‌During my time working with this dynamic marketing team, I learned a lot about customer behavior and marketing strategies. ‌Working closely with some of our long-standing clients, such as Boo, was a particular pleasure.

I would be happy to‌ ‌assist‌ ‌with‌ ‌the‌ ‌transition‌ ‌following‌ ‌my‌ ‌retirement. ‌It would be my pleasure to assist in the hiring or training of‌ ‌my‌ ‌replacement. ‌In order to spend more time with my family, I will also be able to offer part-time consulting services.

After I retire, I plan to cash out the eight unused vacation days I’ve accumulated and take my pension as a lump sum.

Thank you for the opportunity to work with Monters, Inc. ‌In the years to come, I wish you all the best!

Sincerely,

Paul Williams

Sixth Example of Retirement Letter

Dear Micheal,

As In my tenure at Dunder Mifflin Paper Company, I have given everything I had. It has been an honor to work here. But‌ ‌I‌ ‌have‌ ‌decided‌ ‌to‌ ‌move on to new challenges and retire from my position — mainly bears, beets, and Battlestar Galactia.

I appreciate the opportunity to work here and learn so much. During my time at this company, I will always remember the good times and memories we shared. Wishing you all the best in the future.

Sincerely,

Dwight K. Shrute

Your signature

May 16

Seventh Example of Retirement Letter

Greetings, Bill

I am announcing my retirement from Initech, effective March 15, 2023.

Over the course of my career here, I’ve had the privilege of working with so many talented and inspiring people.

In 1999, when I began working as a customer service representative, we were a small organization located in a remote office park.

The fact that we now occupy a floor of the Main Street office building with over 150 employees continues to amaze me.

I am looking forward to spending more time with family and traveling the country in our RV. Although I will be sad to leave.

Please let me know if there are any extra steps I can take to facilitate this transfer.

Sincerely,

Frankin, RenitaEighth Example of Retirement Letter

Height Example of Retirement Letter

Bruce,

Please accept my resignation from Wayne Enterprises as Marketing Communications Director. My last day will be August 1, 2022.

The decision to retire has been made after much deliberation. Now that I have worked in the field for forty years, I believe it is a good time to begin completing my bucket list.

It was not easy for me to decide to leave the company. Having worked at Wayne Enterprises has been rewarding both professionally and personally. There are still a lot of memories associated with my first day as a college intern.

My intention was not to remain with such an innovative company, as you know. I was able to see the big picture with your help, however. Today, we are a force that is recognized both nationally and internationally.

In addition to your guidance, the bold, visionary leadership of our company contributed to the growth of our company.

My departure from the company coincides with a particularly hectic time. Despite my best efforts, I am unable to postpone my exit.

My position would be well served by an internal solution. I have a more than qualified marketing manager in Caroline Crown. It would be a pleasure to speak with you about this.

In case I can be of assistance during the switchover, please let me know. Contact us at (555)555–5555. As part of my responsibilities, I am responsible for making sure all work is completed to Wayne Enterprise’s stringent requirements. Having the opportunity to work with you has been a pleasure. I wish you continued success with your thriving business.

Sincerely,

Cash, Cole

Marketing/Communications

Ninth Example of Retirement Letter

Norman, Jamie

2366 Hanover Street

Whitestone, NY 11357

555–555–5555

jamie.norman@email.com

15 October 2022

Mr. Lippman

Head of Pendant Publishing

600 Madison Ave.

New York, New York

Respected Mr. Lippman,

Please accept my resignation effective‌ ‌November‌ ‌1,‌ ‌2022.

Over the course of my ten years at Pendant Publishing, I’ve had a great deal of fun and I’m quite grateful for all the assistance I’ve received.

It was a pleasure to wake up and go to work every day because of our outstanding corporate culture and the opportunities for promotion and professional advancement available to me.

While‌ ‌I am excited about retiring, I am going to miss being part of our team. ‌It’s my hope that I’ll be able to maintain the friendships I’ve formed here for a long time to come.

In case I can be of assistance prior to or following my departure, please let me know. ‌If I can assist in any way to ensure a smooth transfer to my successor, I would be delighted to do so.

Sincerely,

Signed (hard copy letter)

Norman, Jamie

Tenth Example of Retirement Letter

17 January 2023

Greg S. Jackson

Cyberdyne Systems

18144 El Camino Real,

Sunnyvale, CA

Respected Mrs. Duncan,

I‌ ‌am‌ ‌writing‌ ‌to‌ ‌inform you that I will be resigning from Cyberdyne Systems as of March 1, 2023. I’m grateful to have had this opportunity, and it was a difficult decision to make.

My development as a programmer and as a more seasoned member of the organization has been greatly assisted by your coaching.

I have been proud of Cyberdyne Systems’ ethics and success throughout my 25 years at the company. Starting as a mailroom clerk and currently serving as head programmer.

The portfolios of our clients have always been handled with the greatest care by my colleagues. It is our employees and services that have made Cyberdyne Systems the success it is today.

During my tenure as head of my division, I’ve increased our overall productivity by 800 percent, and I expect that trend to continue after‌ ‌I‌ ‌retire.

In light of the fact that the process of replacing me may take some time, I would like to offer my assistance in any way I can.

The greatest contender for this job is Troy Ledford, my current assistant.

Also, before I leave, I would be willing to teach any partners how to use the programmer I developed to track and manage the development of Skynet.

Over the next few months, I’ll be enjoying vacations with my wife as well as my granddaughter moving‌ ‌to‌ ‌college.

If Cyberdyne Systems has any openings for consultants, please let me know. ‌It has been a pleasure working with you over the last 25 years. I appreciate your concern and care.

Sincerely,

Greg S, Jackson

Questions and Answers

1. What is a letter of retirement?

Retirement letters tell your supervisor you're retiring. This informs your employer that you're departing, like a letter. A resignation letter also requests retirement benefits.

Supervisors frequently receive retirement letters and verbal resignations. Before submitting your retirement letter, meet to discuss your plans. This letter will be filed with your start date, salary, and benefits.

2. Why should you include a letter of retirement?

Your retirement letter should explain why you're leaving. When you quit, your manager and HR department usually know. Regardless, a retirement letter might help you leave on a positive tone. It ensures they have the necessary papers.

In your retirement letter, you tell the firm your plans so they can find your replacement. You may need to stay in touch with your company after sending your retirement letter until a successor is identified.

3. What information ought to be in your retirement letter?

Format it like an official letter. Include your retirement plans and retirement-specific statistics. Date may be most essential.

In some circumstances, benefits depend on when you resign and retire. A date on the letter helps HR or senior management verify when you gave notice and how long.

In addition to your usual salutation, address your letter to your manager or supervisor.

The letter's body should include your retirement date and transition arrangements. Tell them whether you plan to help with the transition or train a new employee. You may have a three-month time limit.

Tell your employer your job title, how long you've worked there, and your biggest successes. Personalize your letter by expressing gratitude for your career and outlining your retirement intentions. Finally, include your contact info.

4. Must I provide notice?

Two-week notice isn't required. Your company may require it. Some state laws contain exceptions.

Check your contract, company handbook, or HR to determine your retirement notice. Resigning may change the policy.

Regardless of your company's policy, notification is standard. Entry-level or junior jobs can be let go so the corporation can replace them.

Middle managers, high-level personnel, and specialists may take months to replace. Two weeks' notice is a courtesy. Start planning months ahead.

You can finish all jobs at that period. Prepare transition documents for coworkers and your replacement.

5. What is the ideal retirement age?

Depends on finances, state, and retirement plan. The average American retires at 62. The average retirement age is 66, according to Gallup's 2021 Economy and Personal Finance Survey.

Remember:

  • Before the age of 59 1/2, withdrawals from pre-tax retirement accounts, such as 401(k)s and IRAs, are subject to a penalty.

  • Benefits from Social Security can be accessed as early as age 62.

  • Medicare isn't available to you till you're 65,

  • Depending on the year of your birth, your Full Retirement Age (FRA) will be between 66 and 67 years old.

  • If you haven't taken them already, your Social Security benefits increase by 8% annually between ages 6 and 77.