Xenobots, tiny living machines, can duplicate themselves.
Strange and complex behavior of frog cell blobs
A xenobot “parent,” shaped like a hungry Pac-Man (shown in red false color), created an “offspring” xenobot (green sphere) by gathering loose frog cells in its opening.
Tiny “living machines” made of frog cells can make copies of themselves. This newly discovered renewal mechanism may help create self-renewing biological machines.
According to Kirstin Petersen, an electrical and computer engineer at Cornell University who studies groups of robots, “this is an extremely exciting breakthrough.” She says self-replicating robots are a big step toward human-free systems.
Researchers described the behavior of xenobots earlier this year (SN: 3/31/21). Small clumps of skin stem cells from frog embryos knitted themselves into small spheres and started moving. Cilia, or cellular extensions, powered the xenobots around their lab dishes.
The findings are published in the Proceedings of the National Academy of Sciences on Dec. 7. The xenobots can gather loose frog cells into spheres, which then form xenobots.
The researchers call this type of movement-induced reproduction kinematic self-replication. The study's coauthor, Douglas Blackiston of Tufts University in Medford, Massachusetts, and Harvard University, says this is typical. For example, sexual reproduction requires parental sperm and egg cells. Sometimes cells split or budded off from a parent.
“This is unique,” Blackiston says. These xenobots “find loose parts in the environment and cobble them together.” This second generation of xenobots can move like their parents, Blackiston says.
The researchers discovered that spheroid xenobots could only produce one more generation before dying out. The original xenobots' shape was predicted by an artificial intelligence program, allowing for four generations of replication.
A C shape, like an openmouthed Pac-Man, was predicted to be a more efficient progenitor. When improved xenobots were let loose in a dish, they began scooping up loose cells into their gaping “mouths,” forming more sphere-shaped bots (see image below). As many as 50 cells clumped together in the opening of a parent to form a mobile offspring. A xenobot is made up of 4,000–6,000 frog cells.
Petersen likes the Xenobots' small size. “The fact that they were able to do this at such a small scale just makes it even better,” she says. Miniature xenobots could sculpt tissues for implantation or deliver therapeutics inside the body.
Beyond the xenobots' potential jobs, the research advances an important science, says study coauthor and Tufts developmental biologist Michael Levin. The science of anticipating and controlling the outcomes of complex systems, he says.
“No one could have predicted this,” Levin says. “They regularly surprise us.” Researchers can use xenobots to test the unexpected. “This is about advancing the science of being less surprised,” Levin says.
More on Science
Bob Service
3 years ago
Did volcanic 'glasses' play a role in igniting early life?
Quenched lava may have aided in the formation of long RNA strands required by primitive life.
It took a long time for life to emerge. Microbes were present 3.7 billion years ago, just a few hundred million years after the 4.5-billion-year-old Earth had cooled enough to sustain biochemistry, according to fossils, and many scientists believe RNA was the genetic material for these first species. RNA, while not as complicated as DNA, would be difficult to forge into the lengthy strands required to transmit genetic information, raising the question of how it may have originated spontaneously.
Researchers may now have a solution. They demonstrate how basaltic glasses assist individual RNA letters, also known as nucleoside triphosphates, join into strands up to 200 letters long in lab studies. The glasses are formed when lava is quenched in air or water, or when melted rock generated by asteroid strikes cools rapidly, and they would have been plentiful in the early Earth's fire and brimstone.
The outcome has caused a schism among top origin-of-life scholars. "This appears to be a great story that finally explains how nucleoside triphosphates react with each other to create RNA strands," says Thomas Carell, a scientist at Munich's Ludwig Maximilians University. However, Harvard University's Jack Szostak, an RNA expert, says he won't believe the results until the study team thoroughly describes the RNA strands.
Researchers interested in the origins of life like the idea of a primordial "RNA universe" since the molecule can perform two different functions that are essential for life. It's made up of four chemical letters, just like DNA, and can carry genetic information. RNA, like proteins, can catalyze chemical reactions that are necessary for life.
However, RNA can cause headaches. No one has yet discovered a set of plausible primordial conditions that would cause hundreds of RNA letters—each of which is a complicated molecule—to join together into strands long enough to support the intricate chemistry required to kick-start evolution.
Basaltic glasses may have played a role, according to Stephen Mojzsis, a geologist at the University of Colorado, Boulder. They're high in metals like magnesium and iron, which help to trigger a variety of chemical reactions. "Basaltic glass was omnipresent on Earth at the time," he adds.
He provided the Foundation for Applied Molecular Evolution samples of five different basalt glasses. Each sample was ground into a fine powder, sanitized, and combined with a solution of nucleoside triphosphates by molecular biologist Elisa Biondi and her colleagues. The RNA letters were unable to link up without the presence of glass powder. However, when the molecules were mixed with the glass particles, they formed long strands of hundreds of letters, according to the researchers, who published their findings in Astrobiology this week. There was no need for heat or light. Biondi explains, "All we had to do was wait." After only a day, little RNA strands produced, yet the strands continued to grow for months. Jan Paek, a molecular biologist at Firebird Biomolecular Sciences, says, "The beauty of this approach is its simplicity." "Mix the components together, wait a few days, and look for RNA."
Nonetheless, the findings pose a slew of problems. One of the questions is how nucleoside triphosphates came to be in the first place. Recent study by Biondi's colleague Steven Benner suggests that the same basaltic glasses may have aided in the creation and stabilization of individual RNA letters.
The form of the lengthy RNA strands, according to Szostak, is a significant challenge. Enzymes in modern cells ensure that most RNAs form long linear chains. RNA letters, on the other hand, can bind in complicated branching sequences. Szostak wants the researchers to reveal what kind of RNA was produced by the basaltic glasses. "It irritates me that the authors made an intriguing initial finding but then chose to follow the hype rather than the research," Szostak says.
Biondi acknowledges that her team's experiment almost probably results in some RNA branching. She does acknowledge, however, that some branched RNAs are seen in species today, and that analogous structures may have existed before the origin of life. Other studies carried out by the study also confirmed the presence of lengthy strands with connections, indicating that they are most likely linear. "It's a healthy argument," says Dieter Braun, a Ludwig Maximilian University origin-of-life chemist. "It will set off the next series of tests."
Michael Hunter, MD
3 years ago
5 Drugs That May Increase Your Risk of Dementia
While our genes can't be changed easily, you can avoid some dementia risk factors. Today we discuss dementia and five drugs that may increase risk.
Memory loss appears to come with age, but we're not talking about forgetfulness. Sometimes losing your car keys isn't an indication of dementia. Dementia impairs the capacity to think, remember, or make judgments. Dementia hinders daily tasks.
Alzheimers is the most common dementia. Dementia is not normal aging, unlike forgetfulness. Aging increases the risk of Alzheimer's and other dementias. A family history of the illness increases your risk, according to the Mayo Clinic (USA).
Given that our genes are difficult to change (I won't get into epigenetics), what are some avoidable dementia risk factors? Certain drugs may cause cognitive deterioration.
Today we look at four drugs that may cause cognitive decline.
Dementia and benzodiazepines
Benzodiazepine sedatives increase brain GABA levels. Example benzodiazepines:
Diazepam (Valium) (Valium)
Alprazolam (Xanax) (Xanax)
Clonazepam (Klonopin) (Klonopin)
Addiction and overdose are benzodiazepine risks. Yes! These medications don't raise dementia risk.
USC study: Benzodiazepines don't increase dementia risk in older adults.
Benzodiazepines can produce short- and long-term amnesia. This memory loss hinders memory formation. Extreme cases can permanently impair learning and memory. Anterograde amnesia is uncommon.
2. Statins and dementia
Statins reduce cholesterol. They prevent a cholesterol-making chemical. Examples:
Atorvastatin (Lipitor) (Lipitor)
Fluvastatin (Lescol XL) (Lescol XL)
Lovastatin (Altoprev) (Altoprev)
Pitavastatin (Livalo, Zypitamag) (Livalo, Zypitamag)
Pravastatin (Pravachol) (Pravachol)
Rosuvastatin (Crestor, Ezallor) (Crestor, Ezallor)
Simvastatin (Zocor) (Zocor)
This finding is contentious. Harvard's Brigham and Womens Hospital's Dr. Joann Manson says:
“I think that the relationship between statins and cognitive function remains controversial. There’s still not a clear conclusion whether they help to prevent dementia or Alzheimer’s disease, have neutral effects, or increase risk.”
This one's off the dementia list.
3. Dementia and anticholinergic drugs
Anticholinergic drugs treat many conditions, including urine incontinence. Drugs inhibit acetylcholine (a brain chemical that helps send messages between cells). Acetylcholine blockers cause drowsiness, disorientation, and memory loss.
First-generation antihistamines, tricyclic antidepressants, and overactive bladder antimuscarinics are common anticholinergics among the elderly.
Anticholinergic drugs may cause dementia. One study found that taking anticholinergics for three years or more increased the risk of dementia by 1.54 times compared to three months or less. After stopping the medicine, the danger may continue.
4. Drugs for Parkinson's disease and dementia
Cleveland Clinic (USA) on Parkinson's:
Parkinson's disease causes age-related brain degeneration. It causes delayed movements, tremors, and balance issues. Some are inherited, but most are unknown. There are various treatment options, but no cure.
Parkinson's medications can cause memory loss, confusion, delusions, and obsessive behaviors. The drug's effects on dopamine cause these issues.
A 2019 JAMA Internal Medicine study found powerful anticholinergic medications enhance dementia risk.
Those who took anticholinergics had a 1.5 times higher chance of dementia. Individuals taking antidepressants, antipsychotic drugs, anti-Parkinson’s drugs, overactive bladder drugs, and anti-epileptic drugs had the greatest risk of dementia.
Anticholinergic medicines can lessen Parkinson's-related tremors, but they slow cognitive ability. Anticholinergics can cause disorientation and hallucinations in those over 70.
5. Antiepileptic drugs and dementia
The risk of dementia from anti-seizure drugs varies with drugs. Levetiracetam (Keppra) improves Alzheimer's cognition.
One study linked different anti-seizure medications to dementia. Anti-epileptic medicines increased the risk of Alzheimer's disease by 1.15 times in the Finnish sample and 1.3 times in the German population. Depakote, Topamax are drugs.
DANIEL CLERY
3 years ago
Can space-based solar power solve Earth's energy problems?
Better technology and lower launch costs revive science-fiction tech.
Airbus engineers showed off sustainable energy's future in Munich last month. They captured sunlight with solar panels, turned it into microwaves, and beamed it into an airplane hangar, where it lighted a city model. The test delivered 2 kW across 36 meters, but it posed a serious question: Should we send enormous satellites to capture solar energy in space? In orbit, free of clouds and nighttime, they could create power 24/7 and send it to Earth.
Airbus engineer Jean-Dominique Coste calls it an engineering problem. “But it’s never been done at [large] scale.”
Proponents of space solar power say the demand for green energy, cheaper space access, and improved technology might change that. Once someone invests commercially, it will grow. Former NASA researcher John Mankins says it might be a trillion-dollar industry.
Myriad uncertainties remain, including whether beaming gigawatts of power to Earth can be done efficiently and without burning birds or people. Concept papers are being replaced with ground and space testing. The European Space Agency (ESA), which supported the Munich demo, will propose ground tests to member nations next month. The U.K. government offered £6 million to evaluate innovations this year. Chinese, Japanese, South Korean, and U.S. agencies are working. NASA policy analyst Nikolai Joseph, author of an upcoming assessment, thinks the conversation's tone has altered. What formerly appeared unattainable may now be a matter of "bringing it all together"
NASA studied space solar power during the mid-1970s fuel crunch. A projected space demonstration trip using 1970s technology would have cost $1 trillion. According to Mankins, the idea is taboo in the agency.
Space and solar power technology have evolved. Photovoltaic (PV) solar cell efficiency has increased 25% over the past decade, Jones claims. Telecoms use microwave transmitters and receivers. Robots designed to repair and refuel spacecraft might create solar panels.
Falling launch costs have boosted the idea. A solar power satellite large enough to replace a nuclear or coal plant would require hundreds of launches. ESA scientist Sanjay Vijendran: "It would require a massive construction complex in orbit."
SpaceX has made the idea more plausible. A SpaceX Falcon 9 rocket costs $2600 per kilogram, less than 5% of what the Space Shuttle did, and the company promised $10 per kilogram for its giant Starship, slated to launch this year. Jones: "It changes the equation." "Economics rules"
Mass production reduces space hardware costs. Satellites are one-offs made with pricey space-rated parts. Mars rover Perseverance cost $2 million per kilogram. SpaceX's Starlink satellites cost less than $1000 per kilogram. This strategy may work for massive space buildings consisting of many identical low-cost components, Mankins has long contended. Low-cost launches and "hypermodularity" make space solar power economical, he claims.
Better engineering can improve economics. Coste says Airbus's Munich trial was 5% efficient, comparing solar input to electricity production. When the Sun shines, ground-based solar arrays perform better. Studies show space solar might compete with existing energy sources on price if it reaches 20% efficiency.
Lighter parts reduce costs. "Sandwich panels" with PV cells on one side, electronics in the middle, and a microwave transmitter on the other could help. Thousands of them build a solar satellite without heavy wiring to move power. In 2020, a team from the U.S. Naval Research Laboratory (NRL) flew on the Air Force's X-37B space plane.
NRL project head Paul Jaffe said the satellite is still providing data. The panel converts solar power into microwaves at 8% efficiency, but not to Earth. The Air Force expects to test a beaming sandwich panel next year. MIT will launch its prototype panel with SpaceX in December.
As a satellite orbits, the PV side of sandwich panels sometimes faces away from the Sun since the microwave side must always face Earth. To maintain 24-hour power, a satellite needs mirrors to keep that side illuminated and focus light on the PV. In a 2012 NASA study by Mankins, a bowl-shaped device with thousands of thin-film mirrors focuses light onto the PV array.
International Electric Company's Ian Cash has a new strategy. His proposed satellite uses enormous, fixed mirrors to redirect light onto a PV and microwave array while the structure spins (see graphic, above). 1 billion minuscule perpendicular antennas act as a "phased array" to electronically guide the beam toward Earth, regardless of the satellite's orientation. This design, argues Cash, is "the most competitive economically"
If a space-based power plant ever flies, its power must be delivered securely and efficiently. Jaffe's team at NRL just beamed 1.6 kW over 1 km, and teams in Japan, China, and South Korea have comparable attempts. Transmitters and receivers lose half their input power. Vijendran says space solar beaming needs 75% efficiency, "preferably 90%."
Beaming gigawatts through the atmosphere demands testing. Most designs aim to produce a beam kilometers wide so every ship, plane, human, or bird that strays into it only receives a tiny—hopefully harmless—portion of the 2-gigawatt transmission. Receiving antennas are cheap to build but require a lot of land, adds Jones. You could grow crops under them or place them offshore.
Europe's public agencies currently prioritize space solar power. Jones: "There's a devotion you don't see in the U.S." ESA commissioned two solar cost/benefit studies last year. Vijendran claims it might match ground-based renewables' cost. Even at a higher price, equivalent to nuclear, its 24/7 availability would make it competitive.
ESA will urge member states in November to fund a technical assessment. If the news is good, the agency will plan for 2025. With €15 billion to €20 billion, ESA may launch a megawatt-scale demonstration facility by 2030 and a gigawatt-scale facility by 2040. "Moonshot"
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Dmytro Spilka
3 years ago
Why NFTs Have a Bright Future Away from Collectible Art After Punks and Apes
After a crazy second half of 2021 and significant trade volumes into 2022, the market for NFT artworks like Bored Ape Yacht Club, CryptoPunks, and Pudgy Penguins has begun a sharp collapse as market downturns hit token values.
DappRadar data shows NFT monthly sales have fallen below $1 billion since June 2021. OpenSea, the world's largest NFT exchange, has seen sales volume decline 75% since May and is trading like July 2021.
Prices of popular non-fungible tokens have also decreased. Bored Ape Yacht Club (BAYC) has witnessed volume and sales drop 63% and 15%, respectively, in the past month.
BeInCrypto analysis shows market decline. May 2022 cryptocurrency marketplace volume was $4 billion, according to a news platform. This is a sharp drop from April's $7.18 billion.
OpenSea, a big marketplace, contributed $2.6 billion, while LooksRare, Magic Eden, and Solanart also contributed.
NFT markets are digital platforms for buying and selling tokens, similar stock trading platforms. Although some of the world's largest exchanges offer NFT wallets, most users store their NFTs on their favorite marketplaces.
In January 2022, overall NFT sales volume was $16.57 billion, with LooksRare contributing $11.1 billion. May 2022's volume was $12.57 less than January, a 75% drop, and June's is expected to be considerably smaller.
A World Based on Utility
Despite declines in NFT trading volumes, not all investors are negative on NFTs. Although there are uncertainties about the sustainability of NFT-based art collections, there are fewer reservations about utility-based tokens and their significance in technology's future.
In June, business CEO Christof Straub said NFTs may help artists monetize unreleased content, resuscitate catalogs, establish deeper fan connections, and make processes more efficient through technology.
We all know NFTs can't be JPEGs. Straub noted that NFT music rights can offer more equitable rewards to musicians.
Music NFTs are here to stay if they have real value, solve real problems, are trusted and lawful, and have fair and sustainable business models.
NFTs can transform numerous industries, including music. Market opinion is shifting towards tokens with more utility than the social media artworks we're used to seeing.
While the major NFT names remain dominant in terms of volume, new utility-based initiatives are emerging as top 20 collections.
Otherdeed, Sorare, and NBA Top Shot are NFT-based games that rank above Bored Ape Yacht Club and Cryptopunks.
Users can switch video NFTs of basketball players in NBA Top Shot. Similar efforts are emerging in the non-fungible landscape.
Sorare shows how NFTs can support a new way of playing fantasy football, where participants buy and swap trading cards to create a 5-player team that wins rewards based on real-life performances.
Sorare raised 579.7 million in one of Europe's largest Series B financing deals in September 2021. Recently, the platform revealed plans to expand into Major League Baseball.
Strong growth indications suggest a promising future for NFTs. The value of art-based collections like BAYC and CryptoPunks may be questioned as markets become diluted by new limited collections, but the potential for NFTs to become intrinsically linked to tangible utility like online gaming, music and art, and even corporate reward schemes shows the industry has a bright future.
Ezra Reguerra
3 years ago
Yuga Labs’ Otherdeeds NFT mint triggers backlash from community
Unhappy community members accuse Yuga Labs of fraud, manipulation, and favoritism over Otherdeeds NFT mint.
Following the Otherdeeds NFT mint, disgruntled community members took to Twitter to criticize Yuga Labs' handling of the event.
Otherdeeds NFTs were a huge hit with the community, selling out almost instantly. Due to high demand, the launch increased Ethereum gas fees from 2.6 ETH to 5 ETH.
But the event displeased many people. Several users speculated that the mint was “planned to fail” so the group could advertise launching its own blockchain, as the team mentioned a chain migration in one tweet.
Others like Mark Beylin tweeted that he had "sold out" on all Ape-related NFT investments after Yuga Labs "revealed their true colors." Beylin also advised others to assume Yuga Labs' owners are “bad actors.”
Some users who failed to complete transactions claim they lost ETH. However, Yuga Labs promised to refund lost gas fees.
CryptoFinally, a Twitter user, claimed Yuga Labs gave BAYC members better land than non-members. Others who wanted to participate paid for shittier land, while BAYCS got the only worthwhile land.
The Otherdeed NFT drop also increased Ethereum's burn rate. Glassnode and Data Always reported nearly 70,000 ETH burned on mint day.
Navdeep Yadav
3 years ago
31 startup company models (with examples)
Many people find the internet's various business models bewildering.
This article summarizes 31 startup e-books.
1. Using the freemium business model (free plus premium),
The freemium business model offers basic software, games, or services for free and charges for enhancements.
Examples include Slack, iCloud, and Google Drive
Provide a rudimentary, free version of your product or service to users.
Google Drive and Dropbox offer 15GB and 2GB of free space but charge for more.
Freemium business model details (Click here)
2. The Business Model of Subscription
Subscription business models sell a product or service for recurring monthly or yearly revenue.
Examples: Tinder, Netflix, Shopify, etc
It's the next step to Freemium if a customer wants to pay monthly for premium features.
Subscription Business Model (Click here)
3. A market-based business strategy
It's an e-commerce site or app where third-party sellers sell products or services.
Examples are Amazon and Fiverr.
On Amazon's marketplace, a third-party vendor sells a product.
Freelancers on Fiverr offer specialized skills like graphic design.
Marketplace's business concept is explained.
4. Business plans using aggregates
In the aggregator business model, the service is branded.
Uber, Airbnb, and other examples
Marketplace and Aggregator business models differ.
Amazon and Fiverr link merchants and customers and take a 10-20% revenue split.
Uber and Airbnb-style aggregator Join these businesses and provide their products.
5. The pay-as-you-go concept of business
This is a consumption-based pricing system. Cloud companies use it.
Example: Amazon Web Service and Google Cloud Platform (GCP) (AWS)
AWS, an Amazon subsidiary, offers over 200 pay-as-you-go cloud services.
“In short, the more you use the more you pay”
When it's difficult to divide clients into pricing levels, pay-as-you is employed.
6. The business model known as fee-for-service (FFS)
FFS charges fixed and variable fees for each successful payment.
For instance, PayU, Paypal, and Stripe
Stripe charges 2.9% + 30 per payment.
These firms offer a payment gateway to take consumer payments and deposit them to a business account.
Fintech business model
7. EdTech business strategy
In edtech, you generate money by selling material or teaching as a service.
edtech business models
Freemium When course content is free but certification isn't, e.g. Coursera
FREE TRIAL SkillShare offers free trials followed by monthly or annual subscriptions.
Self-serving marketplace approach where you pick what to learn.
Ad-revenue model The company makes money by showing adverts to its huge user base.
Lock-in business strategy
Lock in prevents customers from switching to a competitor's brand or offering.
It uses switching costs or effort to transmit (soft lock-in), improved brand experience, or incentives.
Apple, SAP, and other examples
Apple offers an iPhone and then locks you in with extra hardware (Watch, Airpod) and platform services (Apple Store, Apple Music, cloud, etc.).
9. Business Model for API Licensing
APIs let third-party apps communicate with your service.
Uber and Airbnb use Google Maps APIs for app navigation.
Examples are Google Map APIs (Map), Sendgrid (Email), and Twilio (SMS).
Business models for APIs
Free: The simplest API-driven business model that enables unrestricted API access for app developers. Google Translate and Facebook are two examples.
Developer Pays: Under this arrangement, service providers such as AWS, Twilio, Github, Stripe, and others must be paid by application developers.
The developer receives payment: These are the compensated content producers or developers who distribute the APIs utilizing their work. For example, Amazon affiliate programs
10. Open-source enterprise
Open-source software can be inspected, modified, and improved by anybody.
For instance, use Firefox, Java, or Android.
Google paid Mozilla $435,702 million to be their primary search engine in 2018.
Open-source software profits in six ways.
Paid assistance The Project Manager can charge for customization because he is quite knowledgeable about the codebase.
A full database solution is available as a Software as a Service (MongoDB Atlas), but there is a fee for the monitoring tool.
Open-core design R studio is a better GUI substitute for open-source applications.
sponsors of GitHub Sponsorships benefit the developers in full.
demands for paid features Earn Money By Developing Open Source Add-Ons for Current Products
Open-source business model
11. The business model for data
If the software or algorithm collects client data to improve or monetize the system.
Open AI GPT3 gets smarter with use.
Foursquare allows users to exchange check-in locations.
Later, they compiled large datasets to enable retailers like Starbucks launch new outlets.
12. Business Model Using Blockchain
Blockchain is a distributed ledger technology that allows firms to deploy smart contracts without a central authority.
Examples include Alchemy, Solana, and Ethereum.
Business models using blockchain
Economy of tokens or utility When a business uses a token business model, it issues some kind of token as one of the ways to compensate token holders or miners. For instance, Solana and Ethereum
Bitcoin Cash P2P Business Model Peer-to-peer (P2P) blockchain technology permits direct communication between end users. as in IPFS
Enterprise Blockchain as a Service (Baas) BaaS focuses on offering ecosystem services similar to those offered by Amazon (AWS) and Microsoft (Azure) in the web 3 sector. Example: Ethereum Blockchain as a Service with Bitcoin (EBaaS).
Blockchain-Based Aggregators With AWS for blockchain, you can use that service by making an API call to your preferred blockchain. As an illustration, Alchemy offers nodes for many blockchains.
13. The free-enterprise model
In the freeterprise business model, free professional accounts are led into the funnel by the free product and later become B2B/enterprise accounts.
For instance, Slack and Zoom
Freeterprise companies flourish through collaboration.
Start with a free professional account to build an enterprise.
14. Business plan for razor blades
It's employed in hardware where one piece is sold at a loss and profits are made through refills or add-ons.
Gillet razor & blades, coffee machine & beans, HP printer & cartridge, etc.
Sony sells the Playstation console at a loss but makes up for it by selling games and charging for online services.
Advantages of the Razor-Razorblade Method
lowers the risk a customer will try a product. enables buyers to test the goods and services without having to pay a high initial investment.
The product's ongoing revenue stream has the potential to generate sales that much outweigh the original investments.
Razor blade business model
15. The business model of direct-to-consumer (D2C)
In D2C, the company sells directly to the end consumer through its website using a third-party logistic partner.
Examples include GymShark and Kylie Cosmetics.
D2C brands can only expand via websites, marketplaces (Amazon, eBay), etc.
D2C benefits
Lower reliance on middlemen = greater profitability
You now have access to more precise demographic and geographic customer data.
Additional space for product testing
Increased customisation throughout your entire product line-Inventory Less
16. Business model: White Label vs. Private Label
Private label/White label products are made by a contract or third-party manufacturer.
Most amazon electronics are made in china and white-labeled.
Amazon supplements and electronics.
Contract manufacturers handle everything after brands select product quantities on design labels.
17. The franchise model
The franchisee uses the franchisor's trademark, branding, and business strategy (company).
For instance, KFC, Domino's, etc.
Subway, Domino, Burger King, etc. use this business strategy.
Many people pick a franchise because opening a restaurant is risky.
18. Ad-based business model
Social media and search engine giants exploit search and interest data to deliver adverts.
Google, Meta, TikTok, and Snapchat are some examples.
Users don't pay for the service or product given, e.g. Google users don't pay for searches.
In exchange, they collected data and hyper-personalized adverts to maximize revenue.
19. Business plan for octopuses
Each business unit functions separately but is connected to the main body.
Instance: Oyo
OYO is Asia's Airbnb, operating hotels, co-working, co-living, and vacation houses.
20, Transactional business model, number
Sales to customers produce revenue.
E-commerce sites and online purchases employ SSL.
Goli is an ex-GymShark.
21. The peer-to-peer (P2P) business model
In P2P, two people buy and sell goods and services without a third party or platform.
Consider OLX.
22. P2P lending as a manner of operation
In P2P lending, one private individual (P2P Lender) lends/invests or borrows money from another (P2P Borrower).
Instance: Kabbage
Social lending lets people lend and borrow money directly from each other without an intermediary financial institution.
23. A business model for brokers
Brokerages charge a commission or fee for their services.
Examples include eBay, Coinbase, and Robinhood.
Brokerage businesses are common in Real estate, finance, and online and operate on this model.
Buy/sell similar models Examples include financial brokers, insurance brokers, and others who match purchase and sell transactions and charge a commission.
These brokers charge an advertiser a fee based on the date, place, size, or type of an advertisement. This is known as the classified-advertiser model. For instance, Craiglist
24. Drop shipping as an industry
Dropshipping allows stores to sell things without holding physical inventories.
When a customer orders, use a third-party supplier and logistic partners.
Retailer product portfolio and customer experience Fulfiller The consumer places the order.
Dropshipping advantages
Less money is needed (Low overhead-No Inventory or warehousing)
Simple to start (costs under $100)
flexible work environment
New product testing is simpler
25. Business Model for Space as a Service
It's centered on a shared economy that lets millennials live or work in communal areas without ownership or lease.
Consider WeWork and Airbnb.
WeWork helps businesses with real estate, legal compliance, maintenance, and repair.
26. The business model for third-party logistics (3PL)
In 3PL, a business outsources product delivery, warehousing, and fulfillment to an external logistics company.
Examples include Ship Bob, Amazon Fulfillment, and more.
3PL partners warehouse, fulfill, and return inbound and outbound items for a charge.
Inbound logistics involves bringing products from suppliers to your warehouse.
Outbound logistics refers to a company's production line, warehouse, and customer.
27. The last-mile delivery paradigm as a commercial strategy
Last-mile delivery is the collection of supply chain actions that reach the end client.
Examples include Rappi, Gojek, and Postmates.
Last-mile is tied to on-demand and has a nighttime peak.
28. The use of affiliate marketing
Affiliate marketing involves promoting other companies' products and charging commissions.
Examples include Hubspot, Amazon, and Skillshare.
Your favorite youtube channel probably uses these short amazon links to get 5% of sales.
Affiliate marketing's benefits
In exchange for a success fee or commission, it enables numerous independent marketers to promote on its behalf.
Ensure system transparency by giving the influencers a specific tracking link and an online dashboard to view their profits.
Learn about the newest bargains and have access to promotional materials.
29. The business model for virtual goods
This is an in-app purchase for an intangible product.
Examples include PubG, Roblox, Candy Crush, etc.
Consumables are like gaming cash that runs out. Non-consumable products provide a permanent advantage without repeated purchases.
30. Business Models for Cloud Kitchens
Ghost, Dark, Black Box, etc.
Delivery-only restaurant.
These restaurants don't provide dine-in, only delivery.
For instance, NextBite and Faasos
31. Crowdsourcing as a Business Model
Crowdsourcing = Using the crowd as a platform's source.
In crowdsourcing, you get support from people around the world without hiring them.
Crowdsourcing sites
Open-Source Software gives access to the software's source code so that developers can edit or enhance it. Examples include Firefox browsers and Linux operating systems.
Crowdfunding The oculus headgear would be an example of crowdfunding in essence, with no expectations.