More on Science

Sara_Mednick
3 years ago
Since I'm a scientist, I oppose biohacking
Understanding your own energy depletion and restoration is how to truly optimize
Hack has meant many bad things for centuries. In the 1800s, a hack was a meager horse used to transport goods.
Modern usage describes a butcher or ax murderer's cleaver chop. The 1980s programming boom distinguished elegant code from "hacks". Both got you to your goal, but the latter made any programmer cringe and mutter about changing the code. From this emerged the hacker trope, the friendless anti-villain living in a murky hovel lit by the computer monitor, eating junk food and breaking into databases to highlight security system failures or steal hotdog money.
Now, start-a-billion-dollar-business-from-your-garage types have shifted their sights from app development to DIY biology, coining the term "bio-hack". This is a required keyword and meta tag for every fitness-related podcast, book, conference, app, or device.
Bio-hacking involves bypassing your body and mind's security systems to achieve a goal. Many biohackers' initial goals were reasonable, like lowering blood pressure and weight. Encouraged by their own progress, self-determination, and seemingly exquisite control of their biology, they aimed to outsmart aging and death to live 180 to 1000 years (summarized well in this vox.com article).
With this grandiose north star, the hunt for novel supplements and genetic engineering began.
Companies selling do-it-yourself biological manipulations cite lab studies in mice as proof of their safety and success in reversing age-related diseases or promoting longevity in humans (the goal changes depending on whether a company is talking to the federal government or private donors).
The FDA is slower than science, they say. Why not alter your biochemistry by buying pills online, editing your DNA with a CRISPR kit, or using a sauna delivered to your home? How about a microchip or electrical stimulator?
What could go wrong?
I'm not the neo-police, making citizen's arrests every time someone introduces a new plumbing gadget or extrapolates from animal research on resveratrol or catechins that we should drink more red wine or eat more chocolate. As a scientist who's spent her career asking, "Can we get better?" I've come to view bio-hacking as misguided, profit-driven, and counterproductive to its followers' goals.
We're creatures of nature. Despite all the new gadgets and bio-hacks, we still use Roman plumbing technology, and the best way to stay fit, sharp, and happy is to follow a recipe passed down since the beginning of time. Bacteria, plants, and all natural beings are rhythmic, with alternating periods of high activity and dormancy, whether measured in seconds, hours, days, or seasons. Nature repeats successful patterns.
During the Upstate, every cell in your body is naturally primed and pumped full of glycogen and ATP (your cells' energy currencies), as well as cortisol, which supports your muscles, heart, metabolism, cognitive prowess, emotional regulation, and general "get 'er done" attitude. This big energy release depletes your batteries and requires the Downstate, when your subsystems recharge at the cellular level.
Downstates are when you give your heart a break from pumping nutrient-rich blood through your body; when you give your metabolism a break from inflammation, oxidative stress, and sympathetic arousal caused by eating fast food — or just eating too fast; or when you give your mind a chance to wander, think bigger thoughts, and come up with new creative solutions. When you're responding to notifications, emails, and fires, you can't relax.
Downstates aren't just for consistently recharging your battery. By spending time in the Downstate, your body and brain get extra energy and nutrients, allowing you to grow smarter, faster, stronger, and more self-regulated. This state supports half-marathon training, exam prep, and mediation. As we age, spending more time in the Downstate is key to mental and physical health, well-being, and longevity.
When you prioritize energy-demanding activities during Upstate periods and energy-replenishing activities during Downstate periods, all your subsystems, including cardiovascular, metabolic, muscular, cognitive, and emotional, hum along at their optimal settings. When you synchronize the Upstates and Downstates of these individual rhythms, their functioning improves. A hard workout causes autonomic stress, which triggers Downstate recovery.
By choosing the right timing and type of exercise during the day, you can ensure a deeper recovery and greater readiness for the next workout by working with your natural rhythms and strengthening your autonomic and sleep Downstates.
Morning cardio workouts increase deep sleep compared to afternoon workouts. Timing and type of meals determine when your sleep hormone melatonin is released, ushering in sleep.
Rhythm isn't a hack. It's not a way to cheat the system or the boss. Nature has honed its optimization wisdom over trillions of days and nights. Stop looking for quick fixes. You're a whole system made of smaller subsystems that must work together to function well. No one pill or subsystem will make it all work. Understanding and coordinating your rhythms is free, easy, and only benefits you.
Dr. Sara C. Mednick is a cognitive neuroscientist at UC Irvine and author of The Power of the Downstate (HachetteGO)
Jack Burns
3 years ago
Here's what to expect from NASA Artemis 1 and why it's significant.
NASA's Artemis 1 mission will help return people to the Moon after a half-century break. The mission is a shakedown cruise for NASA's Space Launch System and Orion Crew Capsule.
The spaceship will visit the Moon, deploy satellites, and enter orbit. NASA wants to practice operating the spacecraft, test the conditions people will face on the Moon, and ensure a safe return to Earth.
We asked Jack Burns, a space scientist at the University of Colorado Boulder and former member of NASA's Presidential Transition Team, to describe the mission, explain what the Artemis program promises for space exploration, and reflect on how the space program has changed in the half-century since humans last set foot on the moon.
What distinguishes Artemis 1 from other rockets?
Artemis 1 is the Space Launch System's first launch. NASA calls this a "heavy-lift" vehicle. It will be more powerful than Apollo's Saturn V, which transported people to the Moon in the 1960s and 1970s.
It's a new sort of rocket system with two strap-on solid rocket boosters from the space shuttle. It's a mix of the shuttle and Saturn V.
The Orion Crew Capsule will be tested extensively. It'll spend a month in the high-radiation Moon environment. It will also test the heat shield, which protects the capsule and its occupants at 25,000 mph. The heat shield must work well because this is the fastest capsule descent since Apollo.
This mission will also carry miniature Moon-orbiting satellites. These will undertake vital precursor science, including as examining further into permanently shadowed craters where scientists suspect there is water and measuring the radiation environment to see long-term human consequences.
Artemis 1 will launch, fly to the Moon, place satellites, orbit it, return to Earth, and splash down in the ocean. NASA.
What's Artemis's goal? What launches are next?
The mission is a first step toward Artemis 3, which will lead to the first human Moon missions since 1972. Artemis 1 is unmanned.
Artemis 2 will have astronauts a few years later. Like Apollo 8, it will be an orbital mission that circles the Moon and returns. The astronauts will orbit the Moon longer and test everything with a crew.
Eventually, Artemis 3 will meet with the SpaceX Starship on the Moon's surface and transfer people. Orion will stay in orbit while the lunar Starship lands astronauts. They'll go to the Moon's south pole to investigate the water ice there.
Artemis is reminiscent of Apollo. What's changed in 50 years?
Kennedy wanted to beat the Soviets to the Moon with Apollo. The administration didn't care much about space flight or the Moon, but the goal would place America first in space and technology.
You live and die by the sword if you do that. When the U.S. reached the Moon, it was over. Russia lost. We planted flags and did science experiments. Richard Nixon canceled the program after Apollo 11 because the political goals were attained.
Large rocket with two boosters between two gates
NASA's new Space Launch System is brought to a launchpad. NASA
50 years later... It's quite different. We're not trying to beat the Russians, Chinese, or anyone else, but to begin sustainable space exploration.
Artemis has many goals. It includes harnessing in-situ resources like water ice and lunar soil to make food, fuel, and building materials.
SpaceX is part of this first journey to the Moon's surface, therefore the initiative is also helping to develop a lunar and space economy. NASA doesn't own the Starship but is buying seats for astronauts. SpaceX will employ Starship to transport cargo, private astronauts, and foreign astronauts.
Fifty years of technology advancement has made getting to the Moon cheaper and more practical, and computer technology allows for more advanced tests. 50 years of technological progress have changed everything. Anyone with enough money can send a spacecraft to the Moon, but not humans.
Commercial Lunar Payload Services engages commercial companies to develop uncrewed Moon landers. We're sending a radio telescope to the Moon in January. Even 10 years ago, that was impossible.
Since humans last visited the Moon 50 years ago, technology has improved greatly.
What other changes does Artemis have in store?
The government says Artemis 3 will have at least one woman and likely a person of color.
I'm looking forward to seeing more diversity so young kids can say, "Hey, there's an astronaut that looks like me. I can do this. I can be part of the space program.”

Will Lockett
3 years ago
The Unlocking Of The Ultimate Clean Energy
The company seeking 24/7 ultra-powerful solar electricity.
We're rushing to adopt low-carbon energy to prevent a self-made doomsday. We're using solar, wind, and wave energy. These low-carbon sources aren't perfect. They consume large areas of land, causing habitat loss. They don't produce power reliably, necessitating large grid-level batteries, an environmental nightmare. We can and must do better than fossil fuels. Longi, one of the world's top solar panel producers, is creating a low-carbon energy source. Solar-powered spacecraft. But how does it work? Why is it so environmentally harmonious? And how can Longi unlock it?
Space-based solar makes sense. Satellites above Medium Earth Orbit (MEO) enjoy 24/7 daylight. Outer space has no atmosphere or ozone layer to block the Sun's high-energy UV radiation. Solar panels can create more energy in space than on Earth due to these two factors. Solar panels in orbit can create 40 times more power than those on Earth, according to estimates.
How can we utilize this immense power? Launch a geostationary satellite with solar panels, then beam power to Earth. Such a technology could be our most eco-friendly energy source. (Better than fusion power!) How?
Solar panels create more energy in space, as I've said. Solar panel manufacture and grid batteries emit the most carbon. This indicates that a space-solar farm's carbon footprint (which doesn't need a battery because it's a constant power source) might be over 40 times smaller than a terrestrial one. Combine that with carbon-neutral launch vehicles like Starship, and you have a low-carbon power source. Solar power has one of the lowest emissions per kWh at 6g/kWh, so space-based solar could approach net-zero emissions.
Space solar is versatile because it doesn't require enormous infrastructure. A space-solar farm could power New York and Dallas with the same efficiency, without cables. The satellite will transmit power to a nearby terminal. This allows an energy system to evolve and adapt as the society it powers changes. Building and maintaining infrastructure can be carbon-intensive, thus less infrastructure means less emissions.
Space-based solar doesn't destroy habitats, either. Solar and wind power can be engineered to reduce habitat loss, but they still harm ecosystems, which must be restored. Space solar requires almost no land, therefore it's easier on Mother Nature.
Space solar power could be the ultimate energy source. So why haven’t we done it yet?
Well, for two reasons: the cost of launch and the efficiency of wireless energy transmission.
Advances in rocket construction and reusable rocket technology have lowered orbital launch costs. In the early 2000s, the Space Shuttle cost $60,000 per kg launched into LEO, but a SpaceX Falcon 9 costs only $3,205. 95% drop! Even at these low prices, launching a space-based solar farm is commercially questionable.
Energy transmission efficiency is half of its commercial viability. Space-based solar farms must be in geostationary orbit to get 24/7 daylight, 22,300 miles above Earth's surface. It's a long way to wirelessly transmit energy. Most laser and microwave systems are below 20% efficient.
Space-based solar power is uneconomical due to low efficiency and high deployment costs.
Longi wants to create this ultimate power. But how?
They'll send solar panels into space to develop space-based solar power that can be beamed to Earth. This mission will help them design solar panels tough enough for space while remaining efficient.
Longi is a Chinese company, and China's space program and universities are developing space-based solar power and seeking commercial partners. Xidian University has built a 98%-efficient microwave-based wireless energy transmission system for space-based solar power. The Long March 5B is China's super-cheap (but not carbon-offset) launch vehicle.
Longi fills the gap. They have the commercial know-how and ability to build solar satellites and terrestrial terminals at scale. Universities and the Chinese government have transmission technology and low-cost launch vehicles to launch this technology.
It may take a decade to develop and refine this energy solution. This could spark a clean energy revolution. Once operational, Longi and the Chinese government could offer the world a flexible, environmentally friendly, rapidly deployable energy source.
Should the world adopt this technology and let China control its energy? I'm not very political, so you decide. This seems to be the beginning of tapping into this planet-saving energy source. Forget fusion reactors. Carbon-neutral energy is coming soon.
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Bernard Bado
3 years ago
Build This Before Someone Else Does!
Do you want to build and launch your own software company? To do this, all you need is a product that solves a problem.
Coming up with profitable ideas is not that easy. But you’re in luck because you got me!
I’ll give you the idea for free. All you need to do is execute it properly.
If you’re ready, let’s jump right into it! Starting with the problem.
Problem
Youtube has many creators. Every day, they think of new ways to entertain or inform us.
They work hard to make videos. Many of their efforts go to waste. They limit their revenue and reach.
Solution
Content repurposing solves this problem.
One video can become several TikToks. Creating YouTube videos from a podcast episode.
Or, one video might become a blog entry.
By turning videos into blog entries, Youtubers may develop evergreen SEO content, attract a new audience, and reach a non-YouTube audience.
Many YouTube creators want this easy feature.
Let's build it!
Implementation
We identified the problem, and we have a solution. All that’s left to do is see how it can be done.
Monitoring new video uploads
First, watch when a friend uploads a new video. Everything should happen automatically without user input.
YouTube Webhooks make this easy. Our server listens for YouTube Webhook notifications.
After publishing a new video, we create a conversion job.
Creating a Blog Post from a Video
Next, turn a video into a blog article.
To convert, we must extract the video's audio (which can be achieved by using FFmpeg on the server).
Once we have the audio channel, we can use speech-to-text.
Services can accomplish this easily.
Speech-to-text on Google
Google Translate
Deepgram
Deepgram's affordability and integration make it my pick.
After conversion, the blog post needs formatting, error checking, and proofreading.
After this, a new blog post will appear in our web app's dashboard.
Completing a blog post
After conversion, users must examine and amend their blog posts.
Our application dashboard would handle all of this. It's a dashboard-style software where users can:
Link their Youtube account
Check out the converted videos in the future.
View the conversions that are ongoing.
Edit and format converted blog articles.
It's a web-based app.
It doesn't matter how it's made but I'd choose Next.js.
Next.js is a React front-end standard. Vercel serverless functions could conduct the conversions.
This would let me host the software for free and reduce server expenditures.
Taking It One Step Further
SaaS in a nutshell. Future improvements include integrating with WordPress or Ghost.
Our app users could then publish blog posts. Streamlining the procedure.
MVPs don't need this functionality.
Final Thoughts
Repurposing content helps you post more often, reach more people, and develop faster.
Many agencies charge a fortune for this service. Handmade means pricey.
Content creators will go crazy if you automate and cheaply solve this problem.
Just execute this idea!

Joseph Mavericks
3 years ago
The world's 36th richest man uses a 5-step system to get what he wants.
Ray Dalio's super-effective roadmap

Ray Dalio's $22 billion net worth ranks him 36th globally. From 1975 to 2011, he built the world's most successful hedge fund, never losing more than 4% from 1991 to 2020. (and only doing so during 3 calendar years).
Dalio describes a 5-step process in his best-selling book Principles. It's the playbook he's used to build his hedge fund, beat the markets, and face personal challenges.
This 5-step system is so valuable and well-explained that I didn't edit or change anything; I only added my own insights in the parts I found most relevant and/or relatable as a young entrepreneur. The system's overview:
Have clear goals
Identify and don’t tolerate problems
Diagnose problems to get at their root causes
Design plans that will get you around those problems
Do what is necessary to push through the plans to get results
If you follow these 5 steps in a virtuous loop, you'll almost always see results. Repeat the process for each goal you have.

1. Have clear goals
a) Prioritize: You can have almost anything, but not everything.
I started and never launched dozens of projects for 10 years because I was scattered. I opened a t-shirt store, traded algorithms, sold art on Instagram, painted skateboards, and tinkered with electronics. I decided to try blogging for 6 months to see where it took me. Still going after 3 years.
b) Don’t confuse goals with desires.
A goal inspires you to act. Unreasonable desires prevent you from achieving your goals.
c) Reconcile your goals and desires to decide what you want.
d) Don't confuse success with its trappings.
e) Never dismiss a goal as unattainable.
Always one path is best. Your perception of what's possible depends on what you know now. I never thought I'd make money writing online so quickly, and now I see a whole new horizon of business opportunities I didn't know about before.
f) Expectations create abilities.
Don't limit your abilities. More you strive, the more you'll achieve.
g) Flexibility and self-accountability can almost guarantee success.
Flexible people accept what reality or others teach them. Self-accountability is the ability to recognize your mistakes and be more creative, flexible, and determined.
h) Handling setbacks well is as important as moving forward.
Learn when to minimize losses and when to let go and move on.
2. Don't ignore problems
a) See painful problems as improvement opportunities.
Every problem, painful situation, and challenge is an opportunity. Read The Art of Happiness for more.
b) Don't avoid problems because of harsh realities.
Recognizing your weaknesses isn't the same as giving in. It's the first step in overcoming them.
c) Specify your issues.
There is no "one-size-fits-all" solution.
d) Don’t mistake a cause of a problem with the real problem.
"I can't sleep" is a cause, not a problem. "I'm underperforming" could be a problem.
e) Separate big from small problems.
You have limited time and energy, so focus on the biggest problems.
f) Don't ignore a problem.
Identifying a problem and tolerating it is like not identifying it.
3. Identify problems' root causes
a) Decide "what to do" after assessing "what is."
"A good diagnosis takes 15 to 60 minutes, depending on its accuracy and complexity. [...] Like principles, root causes recur in different situations.
b) Separate proximate and root causes.
"You can only solve problems by removing their root causes, and to do that, you must distinguish symptoms from disease."
c) Knowing someone's (or your own) personality can help you predict their behavior.
4. Design plans that will get you around the problems
a) Retrace your steps.
Analyze your past to determine your future.
b) Consider your problem a machine's output.
Consider how to improve your machine. It's a game then.
c) There are many ways to reach your goals.
Find a solution.
d) Visualize who will do what in your plan like a movie script.
Consider your movie's actors and script's turning points, then act accordingly. The game continues.
e) Document your plan so others can judge your progress.
Accountability boosts success.
f) Know that a good plan doesn't take much time.
The execution is usually the hardest part, but most people either don't have a plan or keep changing it. Don't drive while building the car. Build it first, because it'll be bumpy.
5. Do what is necessary to push through the plans to get results
a) Great planners without execution fail.
Life is won with more than just planning. Similarly, practice without talent beats talent without practice.
b) Work ethic is undervalued.
Hyper-productivity is praised in corporate America, even if it leads nowhere. To get things done, use checklists, fewer emails, and more desk time.
c) Set clear metrics to ensure plan adherence.
I've written about the OKR strategy for organizations with multiple people here. If you're on your own, I recommend the Wheel of Life approach. Both systems start with goals and tasks to achieve them. Then start executing on a realistic timeline.
If you find solutions, weaknesses don't matter.
Everyone's weak. You, me, Gates, Dalio, even Musk. Nobody will be great at all 5 steps of the system because no one can think in all the ways required. Some are good at analyzing and diagnosing but bad at executing. Some are good planners but poor communicators. Others lack self-discipline.
Stay humble and ask for help when needed. Nobody has ever succeeded 100% on their own, without anyone else's help. That's the paradox of individual success: teamwork is the only way to get there.
Most people won't have the skills to execute even the best plan. You can get missing skills in two ways:
Self-taught (time-consuming)
Others' (requires humility) light
On knowing what to do with your life
“Some people have good mental maps and know what to do on their own. Maybe they learned them or were blessed with common sense. They have more answers than others. Others are more humble and open-minded. […] Open-mindedness and mental maps are most powerful.” — Ray Dalio
I've always known what I wanted to do, so I'm lucky. I'm almost 30 and have always had trouble executing. Good thing I never stopped experimenting, but I never committed to anything long-term. I jumped between projects. I decided 3 years ago to stick to one project for at least 6 months and haven't looked back.
Maybe you're good at staying focused and executing, but you don't know what to do. Maybe you have none of these because you haven't found your purpose. Always try new projects and talk to as many people as possible. It will give you inspiration and ideas and set you up for success.
There is almost always a way to achieve a crazy goal or idea.
Enjoy the journey, whichever path you take.

Karo Wanner
3 years ago
This is how I started my Twitter account.
My 12-day results look good.
Twitter seemed for old people and politicians.
I thought the platform would die soon like Facebook.
The platform's growth stalled around 300m users between 2015 and 2019.
In 2020, Twitter grew and now has almost 400m users.
Niharikaa Kaur Sodhi built a business on Twitter while I was away, despite its low popularity.
When I read about the success of Twitter users in the past 2 years, I created an account and a 3-month strategy.
I'll see if it's worth starting Twitter in 2022.
Late or perfect? I'll update you. Track my Twitter growth. You can find me here.
My Twitter Strategy
My Twitter goal is to build a community and recruit members for Mindful Monday.
I believe mindfulness is the only way to solve problems like poverty, inequality, and the climate crisis.
The power of mindfulness is my mission.
Mindful Monday is your weekly reminder to live in the present moment. I send mindfulness tips every Monday.
My Twitter profile promotes Mindful Monday and encourages people to join.
What I paid attention to:
I designed a brand-appropriate header to promote Mindful Monday.
Choose a profile picture. People want to know who you are.
I added my name as I do on Medium, Instagram, and emails. To stand out and be easily recognized, add an emoji if appropriate. Add what you want to be known for, such as Health Coach, Writer, or Newsletter.
People follow successful, trustworthy people. Describe any results you have. This could be views, followers, subscribers, or major news outlets. Create!
Tell readers what they'll get by following you. Can you help?
Add CTA to your profile. Your Twitter account's purpose. Give instructions. I placed my sign-up link next to the CTA to promote Mindful Monday. Josh Spector recommended this. (Thanks! Bonus tip: If you don't want the category to show in your profile, e.g. Entrepreneur, go to edit profile, edit professional profile, and choose 'Other'
Here's my Twitter:
I'm no expert, but I tried. Please share any additional Twitter tips and suggestions in the comments.
To hide your Revue newsletter subscriber count:
Join Revue. Select 'Hide Subscriber Count' in Account settings > Settings > Subscriber Count. Voila!
How frequently should you tweet?
1 to 20 Tweets per day, but consistency is key.
Stick to a daily tweet limit. Start with less and be consistent than the opposite.
I tweet 3 times per day. That's my comfort zone. Larger accounts tweet 5–7 times daily.
Do what works for you and that is the right amount.
Twitter is a long-term game, so plan your tweets for a year.
How to Batch Your Tweets?
Sunday batchs.
Sunday evenings take me 1.5 hours to create all my tweets for the week.
Use a word document and write down your posts. Podcasts, books, my own articles inspire me.
When I have a good idea or see a catchy Tweet, I take a screenshot.
To not copy but adapt.
Two pillars support my content:
(90% ~ 29 tweets per week) Inspirational quotes, mindfulness tips, zen stories, mistakes, myths, book recommendations, etc.
(10% 2 tweets per week) I share how I grow Mindful Monday with readers. This pillar promotes MM and behind-the-scenes content.
Second, I schedule all my Tweets using TweetDeck. I tweet at 7 a.m., 5 p.m., and 6 p.m.
Include Twitter Threads in your content strategy
Tweets are blog posts. In your first tweet, you include a headline, then tweet your content.
That’s how you create a series of connected Tweets.
What’s the point? You have more room to convince your reader you're an expert.
Add a call-to-action to your thread.
Follow for more like this
Newsletter signup (share your link)
Ask for retweet
One thread per week is my goal.
I'll schedule threads with Typefully. In the free version, you can schedule one Tweet, but that's fine.
Pin a thread to the top of your profile if it leads to your newsletter. So new readers see your highest-converting content first.
Tweet Medium posts
I also tweet Medium articles.
I schedule 1 weekly repost for 5 weeks after each publication. I share the same article daily for 5 weeks.
Every time I tweet, I include a different article quote, so even if the link is the same, the quote adds value.
Engage Other Experts
When you first create your account, few people will see it. Normal.
If you comment on other industry accounts, you can reach their large audience.
First, you need 50 to 100 followers. Here's my beginner tip.
15 minutes a day or when I have downtime, I comment on bigger accounts in my niche.
My 12-Day Results
Now let's look at the first data.
I had 32 followers on March 29. 12 followers in 11 days. I have 52 now.
Not huge, but growing rapidly.
Let's examine impressions/views.
As a newbie, I gained 4,300 impressions/views in 12 days. On Medium, I got fewer views.
The 1,6k impressions per day spike comes from a larger account I mentioned the day before. First, I was shocked to see the spike and unsure of its origin.
These results are promising given the effort required to be consistent on Twitter.
Let's see how my journey progresses. I'll keep you posted.
Tweeters, Does this content strategy make sense? What's wrong? Comment below.
Let's support each other on Twitter. Here's me.
Which Twitter strategy works for you in 2022?
This post is a summary. Read the full article here