More on Science

Katherine Kornei
3 years ago
The InSight lander from NASA has recorded the greatest tremor ever felt on Mars.
The magnitude 5 earthquake was responsible for the discharge of energy that was 10 times greater than the previous record holder.
Any Martians who happen to be reading this should quickly learn how to duck and cover.
NASA's Jet Propulsion Laboratory in Pasadena, California, reported that on May 4, the planet Mars was shaken by an earthquake of around magnitude 5, making it the greatest Marsquake ever detected to this point. The shaking persisted for more than six hours and unleashed more than ten times as much energy as the earthquake that had previously held the record for strongest.
The event was captured on record by the InSight lander, which is operated by the United States Space Agency and has been researching the innards of Mars ever since it touched down on the planet in 2018 (SN: 11/26/18). The epicenter of the earthquake was probably located in the vicinity of Cerberus Fossae, which is located more than 1,000 kilometers away from the lander.
The surface of Cerberus Fossae is notorious for being broken up and experiencing periodic rockfalls. According to geophysicist Philippe Lognonné, who is the lead investigator of the Seismic Experiment for Interior Structure, the seismometer that is onboard the InSight lander, it is reasonable to assume that the ground is moving in that area. "This is an old crater from a volcanic eruption."
Marsquakes, which are similar to earthquakes in that they give information about the interior structure of our planet, can be utilized to investigate what lies beneath the surface of Mars (SN: 7/22/21). And according to Lognonné, who works at the Institut de Physique du Globe in Paris, there is a great deal that can be gleaned from analyzing this massive earthquake. Because the quality of the signal is so high, we will be able to focus on the specifics.

Sara_Mednick
3 years ago
Since I'm a scientist, I oppose biohacking
Understanding your own energy depletion and restoration is how to truly optimize
Hack has meant many bad things for centuries. In the 1800s, a hack was a meager horse used to transport goods.
Modern usage describes a butcher or ax murderer's cleaver chop. The 1980s programming boom distinguished elegant code from "hacks". Both got you to your goal, but the latter made any programmer cringe and mutter about changing the code. From this emerged the hacker trope, the friendless anti-villain living in a murky hovel lit by the computer monitor, eating junk food and breaking into databases to highlight security system failures or steal hotdog money.
Now, start-a-billion-dollar-business-from-your-garage types have shifted their sights from app development to DIY biology, coining the term "bio-hack". This is a required keyword and meta tag for every fitness-related podcast, book, conference, app, or device.
Bio-hacking involves bypassing your body and mind's security systems to achieve a goal. Many biohackers' initial goals were reasonable, like lowering blood pressure and weight. Encouraged by their own progress, self-determination, and seemingly exquisite control of their biology, they aimed to outsmart aging and death to live 180 to 1000 years (summarized well in this vox.com article).
With this grandiose north star, the hunt for novel supplements and genetic engineering began.
Companies selling do-it-yourself biological manipulations cite lab studies in mice as proof of their safety and success in reversing age-related diseases or promoting longevity in humans (the goal changes depending on whether a company is talking to the federal government or private donors).
The FDA is slower than science, they say. Why not alter your biochemistry by buying pills online, editing your DNA with a CRISPR kit, or using a sauna delivered to your home? How about a microchip or electrical stimulator?
What could go wrong?
I'm not the neo-police, making citizen's arrests every time someone introduces a new plumbing gadget or extrapolates from animal research on resveratrol or catechins that we should drink more red wine or eat more chocolate. As a scientist who's spent her career asking, "Can we get better?" I've come to view bio-hacking as misguided, profit-driven, and counterproductive to its followers' goals.
We're creatures of nature. Despite all the new gadgets and bio-hacks, we still use Roman plumbing technology, and the best way to stay fit, sharp, and happy is to follow a recipe passed down since the beginning of time. Bacteria, plants, and all natural beings are rhythmic, with alternating periods of high activity and dormancy, whether measured in seconds, hours, days, or seasons. Nature repeats successful patterns.
During the Upstate, every cell in your body is naturally primed and pumped full of glycogen and ATP (your cells' energy currencies), as well as cortisol, which supports your muscles, heart, metabolism, cognitive prowess, emotional regulation, and general "get 'er done" attitude. This big energy release depletes your batteries and requires the Downstate, when your subsystems recharge at the cellular level.
Downstates are when you give your heart a break from pumping nutrient-rich blood through your body; when you give your metabolism a break from inflammation, oxidative stress, and sympathetic arousal caused by eating fast food — or just eating too fast; or when you give your mind a chance to wander, think bigger thoughts, and come up with new creative solutions. When you're responding to notifications, emails, and fires, you can't relax.
Downstates aren't just for consistently recharging your battery. By spending time in the Downstate, your body and brain get extra energy and nutrients, allowing you to grow smarter, faster, stronger, and more self-regulated. This state supports half-marathon training, exam prep, and mediation. As we age, spending more time in the Downstate is key to mental and physical health, well-being, and longevity.
When you prioritize energy-demanding activities during Upstate periods and energy-replenishing activities during Downstate periods, all your subsystems, including cardiovascular, metabolic, muscular, cognitive, and emotional, hum along at their optimal settings. When you synchronize the Upstates and Downstates of these individual rhythms, their functioning improves. A hard workout causes autonomic stress, which triggers Downstate recovery.
By choosing the right timing and type of exercise during the day, you can ensure a deeper recovery and greater readiness for the next workout by working with your natural rhythms and strengthening your autonomic and sleep Downstates.
Morning cardio workouts increase deep sleep compared to afternoon workouts. Timing and type of meals determine when your sleep hormone melatonin is released, ushering in sleep.
Rhythm isn't a hack. It's not a way to cheat the system or the boss. Nature has honed its optimization wisdom over trillions of days and nights. Stop looking for quick fixes. You're a whole system made of smaller subsystems that must work together to function well. No one pill or subsystem will make it all work. Understanding and coordinating your rhythms is free, easy, and only benefits you.
Dr. Sara C. Mednick is a cognitive neuroscientist at UC Irvine and author of The Power of the Downstate (HachetteGO)

Sam Warain
3 years ago
Sam Altman, CEO of Open AI, foresees the next trillion-dollar AI company
“I think if I had time to do something else, I would be so excited to go after this company right now.”
Sam Altman, CEO of Open AI, recently discussed AI's present and future.
Open AI is important. They're creating the cyberpunk and sci-fi worlds.
They use the most advanced algorithms and data sets.
GPT-3...sound familiar? Open AI built most copyrighting software. Peppertype, Jasper AI, Rytr. If you've used any, you'll be shocked by the quality.
Open AI isn't only GPT-3. They created DallE-2 and Whisper (a speech recognition software released last week).
What will they do next? What's the next great chance?
Sam Altman, CEO of Open AI, recently gave a lecture about the next trillion-dollar AI opportunity.
Who is the organization behind Open AI?
Open AI first. If you know, skip it.
Open AI is one of the earliest private AI startups. Elon Musk, Greg Brockman, and Rebekah Mercer established OpenAI in December 2015.
OpenAI has helped its citizens and AI since its birth.
They have scary-good algorithms.
Their GPT-3 natural language processing program is excellent.
The algorithm's exponential growth is astounding. GPT-2 came out in November 2019. May 2020 brought GPT-3.
Massive computation and datasets improved the technique in just a year. New York Times said GPT-3 could write like a human.
Same for Dall-E. Dall-E 2 was announced in April 2022. Dall-E 2 won a Colorado art contest.
Open AI's algorithms challenge jobs we thought required human innovation.
So what does Sam Altman think?
The Present Situation and AI's Limitations
During the interview, Sam states that we are still at the tip of the iceberg.
So I think so far, we’ve been in the realm where you can do an incredible copywriting business or you can do an education service or whatever. But I don’t think we’ve yet seen the people go after the trillion dollar take on Google.
He's right that AI can't generate net new human knowledge. It can train and synthesize vast amounts of knowledge, but it simply reproduces human work.
“It’s not going to cure cancer. It’s not going to add to the sum total of human scientific knowledge.”
But the key word is yet.
And that is what I think will turn out to be wrong that most surprises the current experts in the field.
Reinforcing his point that massive innovations are yet to come.
But where?
The Next $1 Trillion AI Company
Sam predicts a bio or genomic breakthrough.
There’s been some promising work in genomics, but stuff on a bench top hasn’t really impacted it. I think that’s going to change. And I think this is one of these areas where there will be these new $100 billion to $1 trillion companies started, and those areas are rare.
Avoid human trials since they take time. Bio-materials or simulators are suitable beginning points.
AI may have a breakthrough. DeepMind, an OpenAI competitor, has developed AlphaFold to predict protein 3D structures.
It could change how we see proteins and their function. AlphaFold could provide fresh understanding into how proteins work and diseases originate by revealing their structure. This could lead to Alzheimer's and cancer treatments. AlphaFold could speed up medication development by revealing how proteins interact with medicines.
Deep Mind offered 200 million protein structures for scientists to download (including sustainability, food insecurity, and neglected diseases).
Being in AI for 4+ years, I'm amazed at the progress. We're past the hype cycle, as evidenced by the collapse of AI startups like C3 AI, and have entered a productive phase.
We'll see innovative enterprises that could replace Google and other trillion-dollar companies.
What happens after AI adoption is scary and unpredictable. How will AGI (Artificial General Intelligence) affect us? Highly autonomous systems that exceed humans at valuable work (Open AI)
My guess is that the things that we’ll have to figure out are how we think about fairly distributing wealth, access to AGI systems, which will be the commodity of the realm, and governance, how we collectively decide what they can do, what they don’t do, things like that. And I think figuring out the answer to those questions is going to just be huge. — Sam Altman CEO
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shivsak
3 years ago
A visual exploration of the REAL use cases for NFTs in the Future
In this essay, I studied REAL NFT use examples and their potential uses.
Knowledge of the Hype Cycle
Gartner's Hype Cycle.
It proposes 5 phases for disruptive technology.
1. Technology Trigger: the emergence of potentially disruptive technology.
2. Peak of Inflated Expectations: Early publicity creates hype. (Ex: 2021 Bubble)
3. Trough of Disillusionment: Early projects fail to deliver on promises and the public loses interest. I suspect NFTs are somewhere around this trough of disillusionment now.
4. Enlightenment slope: The tech shows successful use cases.
5. Plateau of Productivity: Mainstream adoption has arrived and broader market applications have proven themselves. Here’s a more detailed visual of the Gartner Hype Cycle from Wikipedia.
In the speculative NFT bubble of 2021, @beeple sold Everydays: the First 5000 Days for $69 MILLION in 2021's NFT bubble.
@nbatopshot sold millions in video collectibles.
This is when expectations peaked.
Let's examine NFTs' real-world applications.
Watch this video if you're unfamiliar with NFTs.
Online Art
Most people think NFTs are rich people buying worthless JPEGs and MP4s.
Digital artwork and collectibles are revolutionary for creators and enthusiasts.
NFT Profile Pictures
You might also have seen NFT profile pictures on Twitter.
My profile picture is an NFT I coined with @skogards factoria app, which helps me avoid bogus accounts.
Profile pictures are a good beginning point because they're unique and clearly yours.
NFTs are a way to represent proof-of-ownership. It’s easier to prove ownership of digital assets than physical assets, which is why artwork and pfps are the first use cases.
They can do much more.
NFTs can represent anything with a unique owner and digital ownership certificate. Domains and usernames.
Usernames & Domains
@unstoppableweb, @ensdomains, @rarible sell NFT domains.
NFT domains are transferable, which is a benefit.
Godaddy and other web2 providers have difficult-to-transfer domains. Domains are often leased instead of purchased.
Tickets
NFTs can also represent concert tickets and event passes.
There's a limited number, and entry requires proof.
NFTs can eliminate the problem of forgery and make it easy to verify authenticity and ownership.
NFT tickets can be traded on the secondary market, which allows for:
marketplaces that are uniform and offer the seller and buyer security (currently, tickets are traded on inefficient markets like FB & craigslist)
unbiased pricing
Payment of royalties to the creator
4. Historical ticket ownership data implies performers can airdrop future passes, discounts, etc.
5. NFT passes can be a fandom badge.
The $30B+ online tickets business is increasing fast.
NFT-based ticketing projects:
Gaming Assets
NFTs also help in-game assets.
Imagine someone spending five years collecting a rare in-game blade, then outgrowing or quitting the game. Gamers value that collectible.
The gaming industry is expected to make $200 BILLION in revenue this year, a significant portion of which comes from in-game purchases.
Royalties on secondary market trading of gaming assets encourage gaming businesses to develop NFT-based ecosystems.
Digital assets are the start. On-chain NFTs can represent real-world assets effectively.
Real estate has a unique owner and requires ownership confirmation.
Real Estate
Tokenizing property has many benefits.
1. Can be fractionalized to increase access, liquidity
2. Can be collateralized to increase capital efficiency and access to loans backed by an on-chain asset
3. Allows investors to diversify or make bets on specific neighborhoods, towns or cities +++
I've written about this thought exercise before.
I made an animated video explaining this.
We've just explored NFTs for transferable assets. But what about non-transferrable NFTs?
SBTs are Soul-Bound Tokens. Vitalik Buterin (Ethereum co-founder) blogged about this.
NFTs are basically verifiable digital certificates.
Diplomas & Degrees
That fits Degrees & Diplomas. These shouldn't be marketable, thus they can be non-transferable SBTs.
Anyone can verify the legitimacy of on-chain credentials, degrees, abilities, and achievements.
The same goes for other awards.
For example, LinkedIn could give you a verified checkmark for your degree or skills.
Authenticity Protection
NFTs can also safeguard against counterfeiting.
Counterfeiting is the largest criminal enterprise in the world, estimated to be $2 TRILLION a year and growing.
Anti-counterfeit tech is valuable.
This is one of @ORIGYNTech's projects.
Identity
Identity theft/verification is another real-world problem NFTs can handle.
In the US, 15 million+ citizens face identity theft every year, suffering damages of over $50 billion a year.
This isn't surprising considering all you need for US identity theft is a 9-digit number handed around in emails, documents, on the phone, etc.
Identity NFTs can fix this.
NFTs are one-of-a-kind and unforgeable.
NFTs offer a universal standard.
NFTs are simple to verify.
SBTs, or non-transferrable NFTs, are tied to a particular wallet.
In the event of wallet loss or theft, NFTs may be revoked.
This could be one of the biggest use cases for NFTs.
Imagine a global identity standard that is standardized across countries, cannot be forged or stolen, is digital, easy to verify, and protects your private details.
Since your identity is more than your government ID, you may have many NFTs.
@0xPolygon and @civickey are developing on-chain identity.
Memberships
NFTs can authenticate digital and physical memberships.
Voting
NFT IDs can verify votes.
If you remember 2020, you'll know why this is an issue.
Online voting's ease can boost turnout.
Informational property
NFTs can protect IP.
This can earn creators royalties.
NFTs have 2 important properties:
Verifiability IP ownership is unambiguously stated and publicly verified.
Platforms that enable authors to receive royalties on their IP can enter the market thanks to standardization.
Content Rights
Monetization without copyrighting = more opportunities for everyone.
This works well with the music.
Spotify and Apple Music pay creators very little.
Crowdfunding
Creators can crowdfund with NFTs.
NFTs can represent future royalties for investors.
This is particularly useful for fields where people who are not in the top 1% can’t make money. (Example: Professional sports players)
Mirror.xyz allows blog-based crowdfunding.
Financial NFTs
This introduces Financial NFTs (fNFTs). Unique financial contracts abound.
Examples:
a person's collection of assets (unique portfolio)
A loan contract that has been partially repaid with a lender
temporal tokens (ex: veCRV)
Legal Agreements
Not just financial contracts.
NFT can represent any legal contract or document.
Messages & Emails
What about other agreements? Verbal agreements through emails and messages are likewise unique, but they're easily lost and fabricated.
Health Records
Medical records or prescriptions are another types of documentation that has to be verified but isn't.
Medical NFT examples:
Immunization records
Covid test outcomes
Prescriptions
health issues that may affect one's identity
Observations made via health sensors
Existing systems of proof by paper / PDF have photoshop-risk.
I tried to include most use scenarios, but this is just the beginning.
NFTs have many innovative uses.
For example: @ShaanVP minted an NFT called “5 Minutes of Fame” 👇
Here are 2 Twitter threads about NFTs:
This piece of gold by @chriscantino
2. This conversation between @punk6529 and @RaoulGMI on @RealVision“The World According to @punk6529”
If you're wondering why NFTs are better than web2 databases for these use scenarios, see this Twitter thread I wrote:
If you liked this, please share it.

Athirah Syamimi
3 years ago
Here's How I Built A Business Offering Unlimited Design Services in Just One Weekend.
Weekend project: limitless design service. It was fun to see whether I could start a business quickly.
I use no-code apps to save time and resources.
TL;DR I started a business utilizing EditorX for my website, Notion for client project management, and a few favors to finish my portfolio.
First step: research (Day 1)
I got this concept from a Kimp Instagram ad. The Minimalist Hustler Daily newsletter mentioned a similar and cheaper service (Graphically).
I Googled other unlimited design companies. Many provide different costs and services. Some supplied solely graphic design, web development, or copywriting.
Step 2: Brainstorming (Day 1)
I did something simple.
What benefits and services to provide
Price to charge
Since it's a one-person performance (for now), I'm focusing on graphic design. I can charge less.
So I don't overwhelm myself and can accommodate budget-conscious clientele.
Step 3: Construction (Day 1 & 2)
This project includes a management tool, a website, and a team procedure.
I built a project management tool and flow first. Once I had the flow and a Notion board, I tested it with design volunteers. They fake-designed while I built the website.
Tool for Project Management
I modified a Notion template. My goal is to keep clients and designers happy.
Team Approach
My sister, my partner, and I kept this business lean. I tweaked the Notion board to make the process smooth. By the end of Sunday, I’d say it’s perfect!
Website
I created the website after they finished the fake design demands. EditorX's drag-and-drop builder attracted me. I didn't need to learn code, and there are templates.
I used a template wireframe.
This project's hardest aspect is developing the site. It's my first time using EditorX and I'm no developer.
People answer all your inquiries in a large community forum.
As a first-time user developing a site in two days, I think I performed OK. Here's the site for feedback.
4th step: testing (Day 2)
Testing is frustrating because it works or doesn't. My testing day was split in two.
testing the workflow from payment to onboarding to the website
the demand being tested
It's working so far. If someone gets the trial, they can request design work.
I've gotten a couple of inquiries about demand. I’ll be working with them as a start.
Completion
Finally! I built my side project in one weekend. It's too early to tell if this is successful. I liked that I didn't squander months of resources testing out an idea.
Tom Connor
3 years ago
12 mental models that I use frequently
https://tomconnor.me/wp-content/uploads/2021/08/10x-Engineer-Mental-Models.pdf
I keep returning to the same mental models and tricks after writing and reading about a wide range of topics.
Top 12 mental models
12.
Survival bias - We perceive the surviving population as remarkable, yet they may have gotten there through sheer grit.
Survivorship bias affects us in many situations. Our retirement fund; the unicorn business; the winning team. We often study and imitate the last one standing. This can lead to genuine insights and performance improvements, but it can also lead us astray because the leader may just be lucky.
11.
The Helsinki Bus Theory - How to persevere Buss up!
Always display new work, and always be compared to others. Why? Easy. Keep riding. Stay on the fucking bus.
10.
Until it sticks… Turning up every day… — Artists teach engineers plenty. Quality work over a career comes from showing up every day and starting.
9.
WRAP decision making process (Heath Brothers)
Decision-making WRAP Model:
W — Widen your Options
R — Reality test your assumptions
A — Attain Distance
P — Prepare to be wrong or Right
8.
Systems for knowledge worker excellence - Todd Henry and Cal Newport write about techniques knowledge workers can employ to build a creative rhythm and do better work.
Todd Henry's FRESH framework:
Focus: Keep the start in mind as you wrap up.
Relationships: close a loop that's open.
Pruning is an energy.
Set aside time to be inspired by stimuli.
Hours: Spend time thinking.
7.
BBT is learning from mistakes. Science has transformed the world because it constantly updates its theories in light of failures. Complexity guarantees failure. Do we learn or self-justify?
6.
The OODA Loop - Competitive advantage
O: Observe: collect the data. Figure out exactly where you are, what’s happening.
O: Orient: analyze/synthesize the data to form an accurate picture.
D: Decide: select an action from possible options
A: Action: execute the action, and return to step (1)
Boyd's approach indicates that speed and agility are about information processing, not physical reactions. They form feedback loops. More OODA loops improve speed.
5.
Leaders who try to impose order in a complex situation fail; those who set the stage, step back, and allow patterns to develop win.
https://vimeo.com/640941172?embedded=true&source=vimeo_logo&owner=11999906
4.
Information Gap - The discrepancy between what we know and what we would like to know
Gap in Alignment - What individuals actually do as opposed to what we wish them to do
Effects Gap - the discrepancy between our expectations and the results of our actions
3.
Theory of Constraints — The Goal - To maximize system production, maximize bottleneck throughput.
Goldratt creates a five-step procedure:
Determine the restriction
Improve the restriction.
Everything else should be based on the limitation.
Increase the restriction
Go back to step 1 Avoid letting inertia become a limitation.
Any non-constraint improvement is an illusion.
2.
Serendipity and the Adjacent Possible - Why do several amazing ideas emerge at once? How can you foster serendipity in your work?
You need specialized abilities to reach to the edge of possibilities, where you can pursue exciting tasks that will change the world. Few people do it since it takes a lot of hard work. You'll stand out if you do.
Most people simply lack the comfort with discomfort required to tackle really hard things. At some point, in other words, there’s no way getting around the necessity to clear your calendar, shut down your phone, and spend several hard days trying to make sense of the damn proof.
1.
Boundaries of failure - Rasmussen's accident model.
Rasmussen modeled this. It has economic, workload, and performance boundaries.
The economic boundary is a company's profit zone. If the lights are on, you're within the economic boundaries, but there's pressure to cut costs and do more.
Performance limit reflects system capacity. Taking shortcuts is a human desire to minimize work. This is often necessary to survive because there's always more labor.
Both push operating points toward acceptable performance. Personal or process safety, or equipment performance.
If you exceed acceptable performance, you'll push back, typically forcefully.
