More on Science

Will Lockett
3 years ago
Thanks to a recent development, solar energy may prove to be the best energy source.
Perovskite solar cells will revolutionize everything.
Humanity is in a climatic Armageddon. Our widespread ecological crimes of the previous century are catching up with us, and planet-scale karma threatens everyone. We must adjust to new technologies and lifestyles to avoid this fate. Even solar power, a renewable energy source, has climate problems. A recent discovery could boost solar power's eco-friendliness and affordability. Perovskite solar cells are amazing.
Perovskite is a silicon-like semiconductor. Semiconductors are used to make computer chips, LEDs, camera sensors, and solar cells. Silicon makes sturdy and long-lasting solar cells, thus it's used in most modern solar panels.
Perovskite solar cells are far better. First, they're easy to make at room temperature, unlike silicon cells, which require long, intricate baking processes. This makes perovskite cells cheaper to make and reduces their carbon footprint. Perovskite cells are efficient. Most silicon panel solar farms are 18% efficient, meaning 18% of solar radiation energy is transformed into electricity. Perovskite cells are 25% efficient, making them 38% more efficient than silicon.
However, perovskite cells are nowhere near as durable. A normal silicon panel will lose efficiency after 20 years. The first perovskite cells were ineffective since they lasted barely minutes.
Recent research from Princeton shows that perovskite cells can endure 30 years. The cells kept their efficiency, therefore no sacrifices were made.
No electrical or chemical engineer here, thus I can't explain how they did it. But strangely, the team said longevity isn't the big deal. In the next years, perovskite panels will become longer-lasting. How do you test a panel if you only have a month or two? This breakthrough technique needs a uniform method to estimate perovskite life expectancy fast. The study's key milestone was establishing a standard procedure.
Lab-based advanced aging tests are their solution. Perovskite cells decay faster at higher temperatures, so scientists can extrapolate from that. The test heated the panel to 110 degrees and waited for its output to reduce by 20%. Their panel lasted 2,100 hours (87.5 days) before a 20% decline.
They did some math to extrapolate this data and figure out how long the panel would have lasted in different climates, and were shocked to find it would last 30 years in Princeton. This made perovskite panels as durable as silicon panels. This panel could theoretically be sold today.
This technology will soon allow these brilliant panels to be released into the wild. This technology could be commercially viable in ten, maybe five years.
Solar power will be the best once it does. Solar power is cheap and low-carbon. Perovskite is the cheapest renewable energy source if we switch to it. Solar panel manufacturing's carbon footprint will also drop.
Perovskites' impact goes beyond cost and carbon. Silicon panels require harmful mining and contain toxic elements (cadmium). Perovskite panels don't require intense mining or horrible materials, making their production and expiration more eco-friendly.
Solar power destroys habitat. Massive solar farms could reduce biodiversity and disrupt local ecology by destroying vital habitats. Perovskite cells are more efficient, so they can shrink a solar farm while maintaining energy output. This reduces land requirements, making perovskite solar power cheaper, and could reduce solar's environmental impact.
Perovskite solar power is scalable and environmentally friendly. Princeton scientists will speed up the development and rollout of this energy.
Why bother with fusion, fast reactors, SMRs, or traditional nuclear power? We're close to developing a nearly perfect environmentally friendly power source, and we have the tools and systems to do so quickly. It's also affordable, so we can adopt it quickly and let the developing world use it to grow. Even I struggle to justify spending billions on fusion when a great, cheap technology outperforms it. Perovskite's eco-credentials and cost advantages could save the world and power humanity's future.

Laura Sanders
3 years ago
Xenobots, tiny living machines, can duplicate themselves.
Strange and complex behavior of frog cell blobs
A xenobot “parent,” shaped like a hungry Pac-Man (shown in red false color), created an “offspring” xenobot (green sphere) by gathering loose frog cells in its opening.
Tiny “living machines” made of frog cells can make copies of themselves. This newly discovered renewal mechanism may help create self-renewing biological machines.
According to Kirstin Petersen, an electrical and computer engineer at Cornell University who studies groups of robots, “this is an extremely exciting breakthrough.” She says self-replicating robots are a big step toward human-free systems.
Researchers described the behavior of xenobots earlier this year (SN: 3/31/21). Small clumps of skin stem cells from frog embryos knitted themselves into small spheres and started moving. Cilia, or cellular extensions, powered the xenobots around their lab dishes.
The findings are published in the Proceedings of the National Academy of Sciences on Dec. 7. The xenobots can gather loose frog cells into spheres, which then form xenobots.
The researchers call this type of movement-induced reproduction kinematic self-replication. The study's coauthor, Douglas Blackiston of Tufts University in Medford, Massachusetts, and Harvard University, says this is typical. For example, sexual reproduction requires parental sperm and egg cells. Sometimes cells split or budded off from a parent.
“This is unique,” Blackiston says. These xenobots “find loose parts in the environment and cobble them together.” This second generation of xenobots can move like their parents, Blackiston says.
The researchers discovered that spheroid xenobots could only produce one more generation before dying out. The original xenobots' shape was predicted by an artificial intelligence program, allowing for four generations of replication.
A C shape, like an openmouthed Pac-Man, was predicted to be a more efficient progenitor. When improved xenobots were let loose in a dish, they began scooping up loose cells into their gaping “mouths,” forming more sphere-shaped bots (see image below). As many as 50 cells clumped together in the opening of a parent to form a mobile offspring. A xenobot is made up of 4,000–6,000 frog cells.
Petersen likes the Xenobots' small size. “The fact that they were able to do this at such a small scale just makes it even better,” she says. Miniature xenobots could sculpt tissues for implantation or deliver therapeutics inside the body.
Beyond the xenobots' potential jobs, the research advances an important science, says study coauthor and Tufts developmental biologist Michael Levin. The science of anticipating and controlling the outcomes of complex systems, he says.
“No one could have predicted this,” Levin says. “They regularly surprise us.” Researchers can use xenobots to test the unexpected. “This is about advancing the science of being less surprised,” Levin says.

Michael Hunter, MD
3 years ago
5 Drugs That May Increase Your Risk of Dementia
While our genes can't be changed easily, you can avoid some dementia risk factors. Today we discuss dementia and five drugs that may increase risk.
Memory loss appears to come with age, but we're not talking about forgetfulness. Sometimes losing your car keys isn't an indication of dementia. Dementia impairs the capacity to think, remember, or make judgments. Dementia hinders daily tasks.
Alzheimers is the most common dementia. Dementia is not normal aging, unlike forgetfulness. Aging increases the risk of Alzheimer's and other dementias. A family history of the illness increases your risk, according to the Mayo Clinic (USA).
Given that our genes are difficult to change (I won't get into epigenetics), what are some avoidable dementia risk factors? Certain drugs may cause cognitive deterioration.
Today we look at four drugs that may cause cognitive decline.
Dementia and benzodiazepines
Benzodiazepine sedatives increase brain GABA levels. Example benzodiazepines:
Diazepam (Valium) (Valium)
Alprazolam (Xanax) (Xanax)
Clonazepam (Klonopin) (Klonopin)
Addiction and overdose are benzodiazepine risks. Yes! These medications don't raise dementia risk.
USC study: Benzodiazepines don't increase dementia risk in older adults.
Benzodiazepines can produce short- and long-term amnesia. This memory loss hinders memory formation. Extreme cases can permanently impair learning and memory. Anterograde amnesia is uncommon.
2. Statins and dementia
Statins reduce cholesterol. They prevent a cholesterol-making chemical. Examples:
Atorvastatin (Lipitor) (Lipitor)
Fluvastatin (Lescol XL) (Lescol XL)
Lovastatin (Altoprev) (Altoprev)
Pitavastatin (Livalo, Zypitamag) (Livalo, Zypitamag)
Pravastatin (Pravachol) (Pravachol)
Rosuvastatin (Crestor, Ezallor) (Crestor, Ezallor)
Simvastatin (Zocor) (Zocor)
This finding is contentious. Harvard's Brigham and Womens Hospital's Dr. Joann Manson says:
“I think that the relationship between statins and cognitive function remains controversial. There’s still not a clear conclusion whether they help to prevent dementia or Alzheimer’s disease, have neutral effects, or increase risk.”
This one's off the dementia list.
3. Dementia and anticholinergic drugs
Anticholinergic drugs treat many conditions, including urine incontinence. Drugs inhibit acetylcholine (a brain chemical that helps send messages between cells). Acetylcholine blockers cause drowsiness, disorientation, and memory loss.
First-generation antihistamines, tricyclic antidepressants, and overactive bladder antimuscarinics are common anticholinergics among the elderly.
Anticholinergic drugs may cause dementia. One study found that taking anticholinergics for three years or more increased the risk of dementia by 1.54 times compared to three months or less. After stopping the medicine, the danger may continue.
4. Drugs for Parkinson's disease and dementia
Cleveland Clinic (USA) on Parkinson's:
Parkinson's disease causes age-related brain degeneration. It causes delayed movements, tremors, and balance issues. Some are inherited, but most are unknown. There are various treatment options, but no cure.
Parkinson's medications can cause memory loss, confusion, delusions, and obsessive behaviors. The drug's effects on dopamine cause these issues.
A 2019 JAMA Internal Medicine study found powerful anticholinergic medications enhance dementia risk.
Those who took anticholinergics had a 1.5 times higher chance of dementia. Individuals taking antidepressants, antipsychotic drugs, anti-Parkinson’s drugs, overactive bladder drugs, and anti-epileptic drugs had the greatest risk of dementia.
Anticholinergic medicines can lessen Parkinson's-related tremors, but they slow cognitive ability. Anticholinergics can cause disorientation and hallucinations in those over 70.
5. Antiepileptic drugs and dementia
The risk of dementia from anti-seizure drugs varies with drugs. Levetiracetam (Keppra) improves Alzheimer's cognition.
One study linked different anti-seizure medications to dementia. Anti-epileptic medicines increased the risk of Alzheimer's disease by 1.15 times in the Finnish sample and 1.3 times in the German population. Depakote, Topamax are drugs.
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Vanessa Karel
3 years ago
10 hard lessons from founding a startup.
Here is the ugly stuff, read this if you have a founder in your life or are trying to become one. Your call.
#1 You'll try to talk yourself to sleep, but it won't always work.
As founders, we're all driven. Good and bad, you're restless. Success requires resistance and discipline. Your startup will be on your mind 24/7, and not everyone will have the patience to listen to your worries, ideas, and coffee runs. You become more self-sufficient than ever before.
#2 No one will understand what you're going through unless they've been a founder.
Some of my closest friends don't understand the work that goes into starting a business, and we can't blame them.
#3 You'll feel alienated.
Your problems aren't common; calling your bestie won't help. You must search hard for the right resources. It alienates you from conversations you no longer relate to. (No 4th of July, no long weekends!)
#4 Since you're your "own boss," people assume you have lots of free time.
Do you agree? I was on a webinar with lots of new entrepreneurs, and one woman said, "I started my own business so I could have more time for myself." This may be true for some lucky people, and you can be flexible with your schedule. If you want your business to succeed, you'll probably be its slave for a while.
#5 No time for illness or family emergencies.
Both last month. Oh, no! Physically and emotionally withdrawing at the worst times will give you perspective. I learned this the hard way because I was too stubborn to postpone an important interview. I thought if I rested all day and only took one call, I'd be fine. Nope. I had a fever and my mind wasn't as sharp, so my performance and audience interaction suffered. Nope. Better to delay than miss out.
Oh, and setting a "OoO" makes you cringe.
#6 Good luck with your mental health, perfectionists.
When building a startup, it's difficult to accept that there won't be enough time to do everything. You can't make them all, not perfectly. You must learn to accept things that are done but not perfect.
#7 As a founder, you'll make mistakes, but you'll want to make them quickly so you can learn.
Hard lessons are learned quicker. You'll need to pivot and try new things often; some won't work, and it's best to discover them sooner rather than later.
#8 Pyramid schemes abound.
I didn't realize how bad it was until I started a company. You must spy and constantly research. As a founder, you'll receive many emails from people claiming to "support" you. Be wary and keep your eyes open. When it's too good to be true. Some "companies" will try to get you to pay for "competitions" to "pitch at events." Don't do it.
#9 Keep your competitor research to a minimum.
Actually, competition is good. It means there's a market for those solutions. However, this can be mentally exhausting too. Learn about their geography and updates, but that's it.
#10 You'll feel guilty taking vacation.
I don't know what to say, but I no longer enjoy watching TV, and that's okay. Pay attention to things that enrich you, bring you joy, and have fun. It boosts creativity.
Being a startup founder may be one of the hardest professional challenges you face, but it's also a great learning experience. Your passion will take you places you never imagined and open doors to opportunities you wouldn't have otherwise. You'll meet amazing people. No regrets, no complaints. It's a roller coaster, but the good days are great.
Miss anything? Comment below

Tim Soulo
3 years ago
Here is why 90.63% of Pages Get No Traffic From Google.
The web adds millions or billions of pages per day.
How much Google traffic does this content get?
In 2017, we studied 2 million randomly-published pages to answer this question. Only 5.7% of them ranked in Google's top 10 search results within a year of being published.
94.3 percent of roughly two million pages got no Google traffic.
Two million pages is a small sample compared to the entire web. We did another study.
We analyzed over a billion pages to see how many get organic search traffic and why.
How many pages get search traffic?
90% of pages in our index get no Google traffic, and 5.2% get ten visits or less.
90% of google pages get no organic traffic
How can you join the minority that gets Google organic search traffic?
There are hundreds of SEO problems that can hurt your Google rankings. If we only consider common scenarios, there are only four.
Reason #1: No backlinks
I hate to repeat what most SEO articles say, but it's true:
Backlinks boost Google rankings.
Google's "top 3 ranking factors" include them.
Why don't we divide our studied pages by the number of referring domains?
66.31 percent of pages have no backlinks, and 26.29 percent have three or fewer.
Did you notice the trend already?
Most pages lack search traffic and backlinks.
But are these the same pages?
Let's compare monthly organic search traffic to backlinks from unique websites (referring domains):
More backlinks equals more Google organic traffic.
Referring domains and keyword rankings are correlated.
It's important to note that correlation does not imply causation, and none of these graphs prove backlinks boost Google rankings. Most SEO professionals agree that it's nearly impossible to rank on the first page without backlinks.
You'll need high-quality backlinks to rank in Google and get search traffic.
Is organic traffic possible without links?
Here are the numbers:
Four million pages get organic search traffic without backlinks. Only one in 20 pages without backlinks has traffic, which is 5% of our sample.
Most get 300 or fewer organic visits per month.
What happens if we exclude high-Domain-Rating pages?
The numbers worsen. Less than 4% of our sample (1.4 million pages) receive organic traffic. Only 320,000 get over 300 monthly organic visits, or 0.1% of our sample.
This suggests high-authority pages without backlinks are more likely to get organic traffic than low-authority pages.
Internal links likely pass PageRank to new pages.
Two other reasons:
Our crawler's blocked. Most shady SEOs block backlinks from us. This prevents competitors from seeing (and reporting) PBNs.
They choose low-competition subjects. Low-volume queries are less competitive, requiring fewer backlinks to rank.
If the idea of getting search traffic without building backlinks excites you, learn about Keyword Difficulty and how to find keywords/topics with decent traffic potential and low competition.
Reason #2: The page has no long-term traffic potential.
Some pages with many backlinks get no Google traffic.
Why? I filtered Content Explorer for pages with no organic search traffic and divided them into four buckets by linking domains.
Almost 70k pages have backlinks from over 200 domains, but no search traffic.
By manually reviewing these (and other) pages, I noticed two general trends that explain why they get no traffic:
They overdid "shady link building" and got penalized by Google;
They're not targeting a Google-searched topic.
I won't elaborate on point one because I hope you don't engage in "shady link building"
#2 is self-explanatory:
If nobody searches for what you write, you won't get search traffic.
Consider one of our blog posts' metrics:
No organic traffic despite 337 backlinks from 132 sites.
The page is about "organic traffic research," which nobody searches for.
News articles often have this. They get many links from around the web but little Google traffic.
People can't search for things they don't know about, and most don't care about old events and don't search for them.
Note:
Some news articles rank in the "Top stories" block for relevant, high-volume search queries, generating short-term organic search traffic.
The Guardian's top "Donald Trump" story:
Ahrefs caught on quickly:
"Donald Trump" gets 5.6M monthly searches, so this page got a lot of "Top stories" traffic.
I bet traffic has dropped if you check now.
One of the quickest and most effective SEO wins is:
Find your website's pages with the most referring domains;
Do keyword research to re-optimize them for relevant topics with good search traffic potential.
Bryan Harris shared this "quick SEO win" during a course interview:
He suggested using Ahrefs' Site Explorer's "Best by links" report to find your site's most-linked pages and analyzing their search traffic. This finds pages with lots of links but little organic search traffic.
We see:
The guide has 67 backlinks but no organic traffic.
We could fix this by re-optimizing the page for "SERP"
A similar guide with 26 backlinks gets 3,400 monthly organic visits, so we should easily increase our traffic.
Don't do this with all low-traffic pages with backlinks. Choose your battles wisely; some pages shouldn't be ranked.
Reason #3: Search intent isn't met
Google returns the most relevant search results.
That's why blog posts with recommendations rank highest for "best yoga mat."
Google knows that most searchers aren't buying.
It's also why this yoga mats page doesn't rank, despite having seven times more backlinks than the top 10 pages:
The page ranks for thousands of other keywords and gets tens of thousands of monthly organic visits. Not being the "best yoga mat" isn't a big deal.
If you have pages with lots of backlinks but no organic traffic, re-optimizing them for search intent can be a quick SEO win.
It was originally a boring landing page describing our product's benefits and offering a 7-day trial.
We realized the problem after analyzing search intent.
People wanted a free tool, not a landing page.
In September 2018, we published a free tool at the same URL. Organic traffic and rankings skyrocketed.
Reason #4: Unindexed page
Google can’t rank pages that aren’t indexed.
If you think this is the case, search Google for site:[url]. You should see at least one result; otherwise, it’s not indexed.
A rogue noindex meta tag is usually to blame. This tells search engines not to index a URL.
Rogue canonicals, redirects, and robots.txt blocks prevent indexing.
Check the "Excluded" tab in Google Search Console's "Coverage" report to see excluded pages.
Google doesn't index broken pages, even with backlinks.
Surprisingly common.
In Ahrefs' Site Explorer, the Best by Links report for a popular content marketing blog shows many broken pages.
One dead page has 131 backlinks:
According to the URL, the page defined content marketing. —a keyword with a monthly search volume of 5,900 in the US.
Luckily, another page ranks for this keyword. Not a huge loss.
At least redirect the dead page's backlinks to a working page on the same topic. This may increase long-tail keyword traffic.
This post is a summary. See the original post here

Leah
3 years ago
The Burnout Recovery Secrets Nobody Is Talking About
What works and what’s just more toxic positivity
Just keep at it; you’ll get it.
I closed the Zoom call and immediately dropped my head. Open tabs included material on inspiration, burnout, and recovery.
I searched everywhere for ways to avoid burnout.
It wasn't that I needed to keep going, change my routine, employ 8D audio playlists, or come up with fresh ideas. I had several ideas and a schedule. I knew what to do.
I wasn't interested. I kept reading, changing my self-care and mental health routines, and writing even though it was tiring.
Since burnout became a psychiatric illness in 2019, thousands have shared their experiences. It's spreading rapidly among writers.
What is the actual key to recovering from burnout?
Every A-list burnout story emphasizes prevention. Other lists provide repackaged self-care tips. More discuss mental health.
It's like the mid-2000s, when pink quotes about bubble baths saturated social media.
The self-care mania cost us all. Self-care is crucial, but utilizing it to address everything didn't work then or now.
How can you recover from burnout?
Time
Are extended breaks actually good for you? Most people need a break every 62 days or so to avoid burnout.
Real-life burnout victims all took breaks. Perhaps not a long hiatus, but breaks nonetheless.
Burnout is slow and gradual. It takes little bits of your motivation and passion at a time. Sometimes it’s so slow that you barely notice or blame it on other things like stress and poor sleep.
Burnout doesn't come overnight; neither will recovery.
I don’t care what anyone else says the cure for burnout is. It has to be time because time is what gave us all burnout in the first place.
