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Theresa W. Carey

Theresa W. Carey

3 years ago

How Payment for Order Flow (PFOF) Works

What is PFOF?

PFOF is a brokerage firm's compensation for directing orders to different parties for trade execution. The brokerage firm receives fractions of a penny per share for directing the order to a market maker.

Each optionable stock could have thousands of contracts, so market makers dominate options trades. Order flow payments average less than $0.50 per option contract.

Order Flow Payments (PFOF) Explained

The proliferation of exchanges and electronic communication networks has complicated equity and options trading (ECNs) Ironically, Bernard Madoff, the Ponzi schemer, pioneered pay-for-order-flow.

In a December 2000 study on PFOF, the SEC said, "Payment for order flow is a method of transferring trading profits from market making to brokers who route customer orders to specialists for execution."

Given the complexity of trading thousands of stocks on multiple exchanges, market making has grown. Market makers are large firms that specialize in a set of stocks and options, maintaining an inventory of shares and contracts for buyers and sellers. Market makers are paid the bid-ask spread. Spreads have narrowed since 2001, when exchanges switched to decimals. A market maker's ability to play both sides of trades is key to profitability.

Benefits, requirements

A broker receives fees from a third party for order flow, sometimes without a client's knowledge. This invites conflicts of interest and criticism. Regulation NMS from 2005 requires brokers to disclose their policies and financial relationships with market makers.

Your broker must tell you if it's paid to send your orders to specific parties. This must be done at account opening and annually. The firm must disclose whether it participates in payment-for-order-flow and, upon request, every paid order. Brokerage clients can request payment data on specific transactions, but the response takes weeks.

Order flow payments save money. Smaller brokerage firms can benefit from routing orders through market makers and getting paid. This allows brokerage firms to send their orders to another firm to be executed with other orders, reducing costs. The market maker or exchange benefits from additional share volume, so it pays brokerage firms to direct traffic.

Retail investors, who lack bargaining power, may benefit from order-filling competition. Arrangements to steer the business in one direction invite wrongdoing, which can erode investor confidence in financial markets and their players.

Pay-for-order-flow criticism

It has always been controversial. Several firms offering zero-commission trades in the late 1990s routed orders to untrustworthy market makers. During the end of fractional pricing, the smallest stock spread was $0.125. Options spreads widened. Traders found that some of their "free" trades cost them a lot because they weren't getting the best price.

The SEC then studied the issue, focusing on options trades, and nearly decided to ban PFOF. The proliferation of options exchanges narrowed spreads because there was more competition for executing orders. Options market makers said their services provided liquidity. In its conclusion, the report said, "While increased multiple-listing produced immediate economic benefits to investors in the form of narrower quotes and effective spreads, these improvements have been muted with the spread of payment for order flow and internalization." 

The SEC allowed payment for order flow to continue to prevent exchanges from gaining monopoly power. What would happen to trades if the practice was outlawed was also unclear. SEC requires brokers to disclose financial arrangements with market makers. Since then, the SEC has watched closely.

2020 Order Flow Payment

Rule 605 and Rule 606 show execution quality and order flow payment statistics on a broker's website. Despite being required by the SEC, these reports can be hard to find. The SEC mandated these reports in 2005, but the format and reporting requirements have changed over the years, most recently in 2018.

Brokers and market makers formed a working group with the Financial Information Forum (FIF) to standardize order execution quality reporting. Only one retail brokerage (Fidelity) and one market maker remain (Two Sigma Securities). FIF notes that the 605/606 reports "do not provide the level of information that allows a retail investor to gauge how well a broker-dealer fills a retail order compared to the NBBO (national best bid or offer’) at the time the order was received by the executing broker-dealer."

In the first quarter of 2020, Rule 606 reporting changed to require brokers to report net payments from market makers for S&P 500 and non-S&P 500 equity trades and options trades. Brokers must disclose payment rates per 100 shares by order type (market orders, marketable limit orders, non-marketable limit orders, and other orders).

Richard Repetto, Managing Director of New York-based Piper Sandler & Co., publishes a report on Rule 606 broker reports. Repetto focused on Charles Schwab, TD Ameritrade, E-TRADE, and Robinhood in Q2 2020. Repetto reported that payment for order flow was higher in the second quarter than the first due to increased trading activity, and that options paid more than equities.

Repetto says PFOF contributions rose overall. Schwab has the lowest options rates, while TD Ameritrade and Robinhood have the highest. Robinhood had the highest equity rating. Repetto assumes Robinhood's ability to charge higher PFOF reflects their order flow profitability and that they receive a fixed rate per spread (vs. a fixed rate per share by the other brokers).

Robinhood's PFOF in equities and options grew the most quarter-over-quarter of the four brokers Piper Sandler analyzed, as did their implied volumes. All four brokers saw higher PFOF rates.

TD Ameritrade took the biggest income hit when cutting trading commissions in fall 2019, and this report shows they're trying to make up the shortfall by routing orders for additional PFOF. Robinhood refuses to disclose trading statistics using the same metrics as the rest of the industry, offering only a vague explanation on their website.

Summary

Payment for order flow has become a major source of revenue as brokers offer no-commission equity (stock and ETF) orders. For retail investors, payment for order flow poses a problem because the brokerage may route orders to a market maker for its own benefit, not the investor's.

Infrequent or small-volume traders may not notice their broker's PFOF practices. Frequent traders and those who trade larger quantities should learn about their broker's order routing system to ensure they're not losing out on price improvement due to a broker prioritizing payment for order flow.


This post is a summary. Read full article here

More on Economics & Investing

Sam Hickmann

Sam Hickmann

3 years ago

What is headline inflation?

Headline inflation is the raw Consumer price index (CPI) reported monthly by the Bureau of labour statistics (BLS). CPI measures inflation by calculating the cost of a fixed basket of goods. The CPI uses a base year to index the current year's prices.


Explaining Inflation

As it includes all aspects of an economy that experience inflation, headline inflation is not adjusted to remove volatile figures. Headline inflation is often linked to cost-of-living changes, which is useful for consumers.

The headline figure doesn't account for seasonality or volatile food and energy prices, which are removed from the core CPI. Headline inflation is usually annualized, so a monthly headline figure of 4% inflation would equal 4% inflation for the year if repeated for 12 months. Top-line inflation is compared year-over-year.

Inflation's downsides

Inflation erodes future dollar values, can stifle economic growth, and can raise interest rates. Core inflation is often considered a better metric than headline inflation. Investors and economists use headline and core results to set growth forecasts and monetary policy.

Core Inflation

Core inflation removes volatile CPI components that can distort the headline number. Food and energy costs are commonly removed. Environmental shifts that affect crop growth can affect food prices outside of the economy. Political dissent can affect energy costs, such as oil production.

From 1957 to 2018, the U.S. averaged 3.64 percent core inflation. In June 1980, the rate reached 13.60%. May 1957 had 0% inflation. The Fed's core inflation target for 2022 is 3%.
 

Central bank:

A central bank has privileged control over a nation's or group's money and credit. Modern central banks are responsible for monetary policy and bank regulation. Central banks are anti-competitive and non-market-based. Many central banks are not government agencies and are therefore considered politically independent. Even if a central bank isn't government-owned, its privileges are protected by law. A central bank's legal monopoly status gives it the right to issue banknotes and cash. Private commercial banks can only issue demand deposits.

What are living costs?

The cost of living is the amount needed to cover housing, food, taxes, and healthcare in a certain place and time. Cost of living is used to compare the cost of living between cities and is tied to wages. If expenses are higher in a city like New York, salaries must be higher so people can live there.

What's U.S. bureau of labor statistics?

BLS collects and distributes economic and labor market data about the U.S. Its reports include the CPI and PPI, both important inflation measures.

https://www.bls.gov/cpi/

Sofien Kaabar, CFA

Sofien Kaabar, CFA

2 years ago

Innovative Trading Methods: The Catapult Indicator

Python Volatility-Based Catapult Indicator

As a catapult, this technical indicator uses three systems: Volatility (the fulcrum), Momentum (the propeller), and a Directional Filter (Acting as the support). The goal is to get a signal that predicts volatility acceleration and direction based on historical patterns. We want to know when the market will move. and where. This indicator outperforms standard indicators.

Knowledge must be accessible to everyone. This is why my new publications Contrarian Trading Strategies in Python and Trend Following Strategies in Python now include free PDF copies of my first three books (Therefore, purchasing one of the new books gets you 4 books in total). GitHub-hosted advanced indications and techniques are in the two new books above.

The Foundation: Volatility

The Catapult predicts significant changes with the 21-period Relative Volatility Index.

The Average True Range, Mean Absolute Deviation, and Standard Deviation all assess volatility. Standard Deviation will construct the Relative Volatility Index.

Standard Deviation is the most basic volatility. It underpins descriptive statistics and technical indicators like Bollinger Bands. Before calculating Standard Deviation, let's define Variance.

Variance is the squared deviations from the mean (a dispersion measure). We take the square deviations to compel the distance from the mean to be non-negative, then we take the square root to make the measure have the same units as the mean, comparing apples to apples (mean to standard deviation standard deviation). Variance formula:

As stated, standard deviation is:

# The function to add a number of columns inside an array
def adder(Data, times):
    
    for i in range(1, times + 1):
    
        new_col = np.zeros((len(Data), 1), dtype = float)
        Data = np.append(Data, new_col, axis = 1)
        
    return Data

# The function to delete a number of columns starting from an index
def deleter(Data, index, times):
    
    for i in range(1, times + 1):
    
        Data = np.delete(Data, index, axis = 1)
        
    return Data
    
# The function to delete a number of rows from the beginning
def jump(Data, jump):
    
    Data = Data[jump:, ]
    
    return Data

# Example of adding 3 empty columns to an array
my_ohlc_array = adder(my_ohlc_array, 3)

# Example of deleting the 2 columns after the column indexed at 3
my_ohlc_array = deleter(my_ohlc_array, 3, 2)

# Example of deleting the first 20 rows
my_ohlc_array = jump(my_ohlc_array, 20)

# Remember, OHLC is an abbreviation of Open, High, Low, and Close and it refers to the standard historical data file

def volatility(Data, lookback, what, where):
    
  for i in range(len(Data)):

     try:

        Data[i, where] = (Data[i - lookback + 1:i + 1, what].std())
     except IndexError:
        pass
        
  return Data

The RSI is the most popular momentum indicator, and for good reason—it excels in range markets. Its 0–100 range simplifies interpretation. Fame boosts its potential.

The more traders and portfolio managers look at the RSI, the more people will react to its signals, pushing market prices. Technical Analysis is self-fulfilling, therefore this theory is obvious yet unproven.

RSI is determined simply. Start with one-period pricing discrepancies. We must remove each closing price from the previous one. We then divide the smoothed average of positive differences by the smoothed average of negative differences. The RSI algorithm converts the Relative Strength from the last calculation into a value between 0 and 100.

def ma(Data, lookback, close, where): 
    
    Data = adder(Data, 1)
    
    for i in range(len(Data)):
           
            try:
                Data[i, where] = (Data[i - lookback + 1:i + 1, close].mean())
            
            except IndexError:
                pass
            
    # Cleaning
    Data = jump(Data, lookback)
    
    return Data
def ema(Data, alpha, lookback, what, where):
    
    alpha = alpha / (lookback + 1.0)
    beta  = 1 - alpha
    
    # First value is a simple SMA
    Data = ma(Data, lookback, what, where)
    
    # Calculating first EMA
    Data[lookback + 1, where] = (Data[lookback + 1, what] * alpha) + (Data[lookback, where] * beta)    
 
    # Calculating the rest of EMA
    for i in range(lookback + 2, len(Data)):
            try:
                Data[i, where] = (Data[i, what] * alpha) + (Data[i - 1, where] * beta)
        
            except IndexError:
                pass
            
    return Datadef rsi(Data, lookback, close, where, width = 1, genre = 'Smoothed'):
    
    # Adding a few columns
    Data = adder(Data, 7)
    
    # Calculating Differences
    for i in range(len(Data)):
        
        Data[i, where] = Data[i, close] - Data[i - width, close]
     
    # Calculating the Up and Down absolute values
    for i in range(len(Data)):
        
        if Data[i, where] > 0:
            
            Data[i, where + 1] = Data[i, where]
            
        elif Data[i, where] < 0:
            
            Data[i, where + 2] = abs(Data[i, where])
            
    # Calculating the Smoothed Moving Average on Up and Down
    absolute values        
                             
    lookback = (lookback * 2) - 1 # From exponential to smoothed
    Data = ema(Data, 2, lookback, where + 1, where + 3)
    Data = ema(Data, 2, lookback, where + 2, where + 4)
    
    # Calculating the Relative Strength
    Data[:, where + 5] = Data[:, where + 3] / Data[:, where + 4]
    
    # Calculate the Relative Strength Index
    Data[:, where + 6] = (100 - (100 / (1 + Data[:, where + 5])))  
    
    # Cleaning
    Data = deleter(Data, where, 6)
    Data = jump(Data, lookback)

    return Data
EURUSD in the first panel with the 21-period RVI in the second panel.
def relative_volatility_index(Data, lookback, close, where):

    # Calculating Volatility
    Data = volatility(Data, lookback, close, where)
    
    # Calculating the RSI on Volatility
    Data = rsi(Data, lookback, where, where + 1) 
    
    # Cleaning
    Data = deleter(Data, where, 1)
    
    return Data

The Arm Section: Speed

The Catapult predicts momentum direction using the 14-period Relative Strength Index.

EURUSD in the first panel with the 14-period RSI in the second panel.

As a reminder, the RSI ranges from 0 to 100. Two levels give contrarian signals:

  • A positive response is anticipated when the market is deemed to have gone too far down at the oversold level 30, which is 30.

  • When the market is deemed to have gone up too much, at overbought level 70, a bearish reaction is to be expected.

Comparing the RSI to 50 is another intriguing use. RSI above 50 indicates bullish momentum, while below 50 indicates negative momentum.

The direction-finding filter in the frame

The Catapult's directional filter uses the 200-period simple moving average to keep us trending. This keeps us sane and increases our odds.

Moving averages confirm and ride trends. Its simplicity and track record of delivering value to analysis make them the most popular technical indicator. They help us locate support and resistance, stops and targets, and the trend. Its versatility makes them essential trading tools.

EURUSD hourly values with the 200-hour simple moving average.

This is the plain mean, employed in statistics and everywhere else in life. Simply divide the number of observations by their total values. Mathematically, it's:

We defined the moving average function above. Create the Catapult indication now.

Indicator of the Catapult

The indicator is a healthy mix of the three indicators:

  • The first trigger will be provided by the 21-period Relative Volatility Index, which indicates that there will now be above average volatility and, as a result, it is possible for a directional shift.

  • If the reading is above 50, the move is likely bullish, and if it is below 50, the move is likely bearish, according to the 14-period Relative Strength Index, which indicates the likelihood of the direction of the move.

  • The likelihood of the move's direction will be strengthened by the 200-period simple moving average. When the market is above the 200-period moving average, we can infer that bullish pressure is there and that the upward trend will likely continue. Similar to this, if the market falls below the 200-period moving average, we recognize that there is negative pressure and that the downside is quite likely to continue.

lookback_rvi = 21
lookback_rsi = 14
lookback_ma  = 200
my_data = ma(my_data, lookback_ma, 3, 4)
my_data = rsi(my_data, lookback_rsi, 3, 5)
my_data = relative_volatility_index(my_data, lookback_rvi, 3, 6)

Two-handled overlay indicator Catapult. The first exhibits blue and green arrows for a buy signal, and the second shows blue and red for a sell signal.

The chart below shows recent EURUSD hourly values.

Signal chart.
def signal(Data, rvi_col, signal):
    
    Data = adder(Data, 10)
        
    for i in range(len(Data)):
            
        if Data[i,     rvi_col] < 30 and \
           Data[i - 1, rvi_col] > 30 and \
           Data[i - 2, rvi_col] > 30 and \
           Data[i - 3, rvi_col] > 30 and \
           Data[i - 4, rvi_col] > 30 and \
           Data[i - 5, rvi_col] > 30:
               
               Data[i, signal] = 1
                           
    return Data
Signal chart.

Signals are straightforward. The indicator can be utilized with other methods.

my_data = signal(my_data, 6, 7)
Signal chart.

Lumiwealth shows how to develop all kinds of algorithms. I recommend their hands-on courses in algorithmic trading, blockchain, and machine learning.

Summary

To conclude, my goal is to contribute to objective technical analysis, which promotes more transparent methods and strategies that must be back-tested before implementation. Technical analysis will lose its reputation as subjective and unscientific.

After you find a trading method or approach, follow these steps:

  • Put emotions aside and adopt an analytical perspective.

  • Test it in the past in conditions and simulations taken from real life.

  • Try improving it and performing a forward test if you notice any possibility.

  • Transaction charges and any slippage simulation should always be included in your tests.

  • Risk management and position sizing should always be included in your tests.

After checking the aforementioned, monitor the plan because market dynamics may change and render it unprofitable.

Trevor Stark

Trevor Stark

3 years ago

Economics is complete nonsense.

Mainstream economics haven't noticed.

Photo by Hans Eiskonen on Unsplash

What come to mind when I say the word "economics"?

Probably GDP, unemployment, and inflation.

If you've ever watched the news or listened to an economist, they'll use data like these to defend a political goal.

The issue is that these statistics are total bunk.

I'm being provocative, but I mean it:

  • The economy is not measured by GDP.

  • How many people are unemployed is not counted in the unemployment rate.

  • Inflation is not measured by the CPI.

All orthodox economists' major economic statistics are either wrong or falsified.

Government institutions create all these stats. The administration wants to reassure citizens the economy is doing well.

GDP does not reflect economic expansion.

GDP measures a country's economic size and growth. It’s calculated by the BEA, a government agency.

The US has the world's largest (self-reported) GDP, growing 2-3% annually.

If GDP rises, the economy is healthy, say economists.

Why is the GDP flawed?

GDP measures a country's yearly spending.

The government may adjust this to make the economy look good.

GDP = C + G + I + NX

C = Consumer Spending

G = Government Spending

I = Investments (Equipment, inventories, housing, etc.)

NX = Exports minus Imports

GDP is a country's annual spending.

The government can print money to boost GDP. The government has a motive to increase and manage GDP.

Because government expenditure is part of GDP, printing money and spending it on anything will raise GDP.

They've done this. Since 1950, US government spending has grown 8% annually, faster than GDP.

In 2022, government spending accounted for 44% of GDP. It's the highest since WWII. In 1790-1910, it was 3% of GDP.

Who cares?

The economy isn't only spending. Focus on citizens' purchasing power or quality of life.

Since GDP just measures spending, the government can print money to boost GDP.

Even if Americans are poorer than last year, economists can say GDP is up and everything is fine.

How many people are unemployed is not counted in the unemployment rate.

The unemployment rate measures a country's labor market. If unemployment is high, people aren't doing well economically.

The BLS estimates the (self-reported) unemployment rate as 3-4%.

Why is the unemployment rate so high?

The US government surveys 100k persons to measure unemployment. They extrapolate this data for the country.

They come into 3 categories:

  • Employed

People with jobs are employed … duh.

  • Unemployed

People who are “jobless, looking for a job, and available for work” are unemployed

  • Not in the labor force

The “labor force” is the employed + the unemployed.

The unemployment rate is the percentage of unemployed workers.

Problem is unemployed definition. You must actively seek work to be considered unemployed.

You're no longer unemployed if you haven't interviewed in 4 weeks.

This shit makes no goddamn sense.

Why does this matter?

You can't interview if there are no positions available. You're no longer unemployed after 4 weeks.

In 1994, the BLS redefined "unemployed" to exclude discouraged workers.

If you haven't interviewed in 4 weeks, you're no longer counted in the unemployment rate.

Unemployment Data Including “Long-term Discouraged Workers” (Source)

If unemployment were measured by total unemployed, it would be 25%.

Because the government wants to keep the unemployment rate low, they modify the definition.

If every US resident was unemployed and had no job interviews, economists would declare 0% unemployment. Excellent!

Inflation is not measured by the CPI.

The BLS measures CPI. This month was the highest since 1981.

CPI measures the cost of a basket of products across time. Food, energy, shelter, and clothes are included.

A 9.1% CPI means the basket of items is 9.1% more expensive.

What is the CPI problem?

Here's a more detailed explanation of CPI's flaws.

In summary, CPI is manipulated to be understated.

Housing costs are understated to manipulate CPI. Housing accounts for 33% of the CPI because it's the biggest expense for most people.

This signifies it's the biggest CPI weight.

Rather than using actual house prices, the Bureau of Labor Statistics essentially makes shit up. You can read more about the process here.

Surprise! It’s bullshit

The BLS stated Shelter's price rose 5.5% this month.

House prices are up 11-21%. (Source 1Source 2Source 3)

Rents are up 14-26%. (Source 1Source 2)

Why is this important?

If CPI included housing prices, it would be 12-15 percent this month, not 9.1 percent.

9% inflation is nuts. Your money's value halves every 7 years at 9% inflation.

Worse is 15% inflation. Your money halves every 4 years at 15% inflation.

If everyone realized they needed to double their wage every 4-5 years to stay wealthy, there would be riots.

Inflation drains our money's value so the government can keep printing it.

The Solution

Most individuals know the existing system doesn't work, but can't explain why.

People work hard yet lag behind. The government lies about the economy's data.

In reality:

  • GDP has been down since 2008

  • 25% of Americans are unemployed

  • Inflation is actually 15%

People might join together to vote out kleptocratic politicians if they knew the reality.

Having reliable economic data is the first step.

People can't understand the situation without sufficient information. Instead of immigrants or billionaires, people would blame liar politicians.

Here’s the vision:

A decentralized, transparent, and global dashboard that tracks economic data like GDP, unemployment, and inflation for every country on Earth.

Government incentives influence economic statistics.

ShadowStats has already started this effort, but the calculations must be transparent, decentralized, and global to be effective.

If interested, email me at trevorstark02@gmail.com.

Here are some links to further your research:

  1. MIT Billion Prices Project

  2. 1729 Decentralized Inflation Dashboard Project

  3. Balaji Srinivasan on “Fiat Information VS. Crypto Information”

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Michael Hunter, MD

Michael Hunter, MD

2 years ago

5 Drugs That May Increase Your Risk of Dementia

Photo by danilo.alvesd on Unsplash

While our genes can't be changed easily, you can avoid some dementia risk factors. Today we discuss dementia and five drugs that may increase risk.

Memory loss appears to come with age, but we're not talking about forgetfulness. Sometimes losing your car keys isn't an indication of dementia. Dementia impairs the capacity to think, remember, or make judgments. Dementia hinders daily tasks.

Alzheimers is the most common dementia. Dementia is not normal aging, unlike forgetfulness. Aging increases the risk of Alzheimer's and other dementias. A family history of the illness increases your risk, according to the Mayo Clinic (USA).

Given that our genes are difficult to change (I won't get into epigenetics), what are some avoidable dementia risk factors? Certain drugs may cause cognitive deterioration.

Today we look at four drugs that may cause cognitive decline.

Dementia and benzodiazepines

Benzodiazepine sedatives increase brain GABA levels. Example benzodiazepines:

  • Diazepam (Valium) (Valium)

  • Alprazolam (Xanax) (Xanax)

  • Clonazepam (Klonopin) (Klonopin)

Addiction and overdose are benzodiazepine risks. Yes! These medications don't raise dementia risk.

USC study: Benzodiazepines don't increase dementia risk in older adults.

Benzodiazepines can produce short- and long-term amnesia. This memory loss hinders memory formation. Extreme cases can permanently impair learning and memory. Anterograde amnesia is uncommon.

2. Statins and dementia

Statins reduce cholesterol. They prevent a cholesterol-making chemical. Examples:

  • Atorvastatin (Lipitor) (Lipitor)

  • Fluvastatin (Lescol XL) (Lescol XL)

  • Lovastatin (Altoprev) (Altoprev)

  • Pitavastatin (Livalo, Zypitamag) (Livalo, Zypitamag)

  • Pravastatin (Pravachol) (Pravachol)

  • Rosuvastatin (Crestor, Ezallor) (Crestor, Ezallor)

  • Simvastatin (Zocor) (Zocor)

Photo by Towfiqu barbhuiya on Unsplash

This finding is contentious. Harvard's Brigham and Womens Hospital's Dr. Joann Manson says:

“I think that the relationship between statins and cognitive function remains controversial. There’s still not a clear conclusion whether they help to prevent dementia or Alzheimer’s disease, have neutral effects, or increase risk.”

This one's off the dementia list.

3. Dementia and anticholinergic drugs

Anticholinergic drugs treat many conditions, including urine incontinence. Drugs inhibit acetylcholine (a brain chemical that helps send messages between cells). Acetylcholine blockers cause drowsiness, disorientation, and memory loss.

First-generation antihistamines, tricyclic antidepressants, and overactive bladder antimuscarinics are common anticholinergics among the elderly.

Anticholinergic drugs may cause dementia. One study found that taking anticholinergics for three years or more increased the risk of dementia by 1.54 times compared to three months or less. After stopping the medicine, the danger may continue.

4. Drugs for Parkinson's disease and dementia

Cleveland Clinic (USA) on Parkinson's:

Parkinson's disease causes age-related brain degeneration. It causes delayed movements, tremors, and balance issues. Some are inherited, but most are unknown. There are various treatment options, but no cure.

Parkinson's medications can cause memory loss, confusion, delusions, and obsessive behaviors. The drug's effects on dopamine cause these issues.

A 2019 JAMA Internal Medicine study found powerful anticholinergic medications enhance dementia risk.

Those who took anticholinergics had a 1.5 times higher chance of dementia. Individuals taking antidepressants, antipsychotic drugs, anti-Parkinson’s drugs, overactive bladder drugs, and anti-epileptic drugs had the greatest risk of dementia.

Anticholinergic medicines can lessen Parkinson's-related tremors, but they slow cognitive ability. Anticholinergics can cause disorientation and hallucinations in those over 70.

Photo by Wengang Zhai on Unsplash

5. Antiepileptic drugs and dementia

The risk of dementia from anti-seizure drugs varies with drugs. Levetiracetam (Keppra) improves Alzheimer's cognition.

One study linked different anti-seizure medications to dementia. Anti-epileptic medicines increased the risk of Alzheimer's disease by 1.15 times in the Finnish sample and 1.3 times in the German population. Depakote, Topamax are drugs.

Antonio Neto

Antonio Neto

3 years ago

What's up with tech?

Massive Layoffs, record low VC investment, debate over crash... why is it happening and what’s the endgame?

This article generalizes a diverse industry. For objectivity, specific tech company challenges like growing competition within named segments won't be considered. Please comment on the posts.

According to Layoffs.fyi, nearly 120.000 people have been fired from startups since March 2020. More than 700 startups have fired 1% to 100% of their workforce. "The tech market is crashing"

Venture capital investment dropped 19% QoQ in the first four months of 2022, a 2018 low. Since January 2022, Nasdaq has dropped 27%. Some believe the tech market is collapsing.

It's bad, but nothing has crashed yet. We're about to get super technical, so buckle up!

I've written a follow-up article about what's next. For a more optimistic view of the crisis' aftermath, see: Tech Diaspora and Silicon Valley crisis

What happened?

Insanity reigned. Last decade, everyone became a unicorn. Seed investments can be made without a product or team. While the "real world" economy suffered from the pandemic for three years, tech companies enjoyed the "new normal."

COVID sped up technology adoption on several fronts, but this "new normal" wasn't so new after many restrictions were lifted. Worse, it lived with disrupted logistics chains, high oil prices, and WW3. The consumer market has felt the industry's boom for almost 3 years. Inflation, unemployment, mental distress...what looked like a fast economic recovery now looks like unfulfilled promises.

People rethink everything they eat. Paying a Netflix subscription instead of buying beef is moronic if you can watch it for free on your cousin’s account. No matter how great your real estate app's UI is, buying a house can wait until mortgage rates drop. PLGProduct Led Growth (PLG) isn't the go-to strategy when consumers have more basic expense priorities.

Exponential growth and investment

Until recently, tech companies believed that non-exponential revenue growth was fatal. Exponential growth entails doing more with less. From Salim Ismail words:

An Exponential Organization (ExO) has 10x the impact of its peers.

Many tech companies' theories are far from reality.

Investors have funded (sometimes non-exponential) growth. Scale-driven companies throw people at problems until they're solved. Need an entire closing team because you’ve just bought a TV prime time add? Sure. Want gold-weight engineers to colorize buttons? Why not?

Tech companies don't need cash flow to do it; they can just show revenue growth and get funding. Even though it's hard to get funding, this was the market's momentum until recently.

The graph at the beginning of this section shows how industry heavyweights burned money until 2020, despite being far from their market-share seed stage. Being big and being sturdy are different things, and a lot of the tech startups out there are paper tigers. Without investor money, they have no foundation.

A little bit about interest rates

Inflation-driven high interest rates are said to be causing tough times. Investors would rather leave money in the bank than spend it (I myself said it some days ago). It’s not wrong, but it’s also not that simple.

The USA central bank (FED) is a good proxy of global economics. Dollar treasury bonds are the safest investment in the world. Buying U.S. debt, the only country that can print dollars, guarantees payment.

The graph above shows that FED interest rates are low and 10+ year bond yields are near 2018 levels. Nobody was firing at 2018. What’s with that then?

Full explanation is too technical for this article, so I'll just summarize: Bond yields rise due to lack of demand or market expectations of longer-lasting inflation. Safe assets aren't a "easy money" tactic for investors. If that were true, we'd have seen the current scenario before.

Long-term investors are protecting their capital from inflation.

Not a crash, a landing

I bombarded you with info... Let's review:

  • Consumption is down, hurting revenue.

  • Tech companies of all ages have been hiring to grow revenue at the expense of profit.

  • Investors expect inflation to last longer, reducing future investment gains.

Inflation puts pressure on a wheel that was rolling full speed not long ago. Investment spurs hiring, growth, and more investment. Worried investors and consumers reduce the cycle, and hiring follows.

Long-term investors back startups. When the invested company goes public or is sold, it's ok to burn money. What happens when the payoff gets further away? What if all that money sinks? Investors want immediate returns.

Why isn't the market crashing? Technology is not losing capital. It’s expecting change. The market realizes it threw moderation out the window and is reversing course. Profitability is back on the menu.

People solve problems and make money, but they also cost money. Huge cost for the tech industry. Engineers, Product Managers, and Designers earn up to 100% more than similar roles. Businesses must be careful about who they keep and in what positions to avoid wasting money.

What the future holds

From here on, it's all speculation. I found many great articles while researching this piece. Some are cited, others aren't (like this and this). We're in an adjustment period that may or may not last long.

Big companies aren't laying off many workers. Netflix firing 100 people makes headlines, but it's only 1% of their workforce. The biggest seem to prefer not hiring over firing.

Smaller startups beyond the seeding stage may be hardest hit. Without structure or product maturity, many will die.

I expect layoffs to continue for some time, even at Meta or Amazon. I don't see any industry names falling like they did during the .com crisis, but the market will shrink.

If you are currently employed, think twice before moving out and where to.
If you've been fired, hurry, there are still many opportunities.
If you're considering a tech career, wait.
If you're starting a business, I respect you. Good luck.

Katherine Kornei

Katherine Kornei

3 years ago

The InSight lander from NASA has recorded the greatest tremor ever felt on Mars.

The magnitude 5 earthquake was responsible for the discharge of energy that was 10 times greater than the previous record holder.

Any Martians who happen to be reading this should quickly learn how to duck and cover.

NASA's Jet Propulsion Laboratory in Pasadena, California, reported that on May 4, the planet Mars was shaken by an earthquake of around magnitude 5, making it the greatest Marsquake ever detected to this point. The shaking persisted for more than six hours and unleashed more than ten times as much energy as the earthquake that had previously held the record for strongest.

The event was captured on record by the InSight lander, which is operated by the United States Space Agency and has been researching the innards of Mars ever since it touched down on the planet in 2018 (SN: 11/26/18). The epicenter of the earthquake was probably located in the vicinity of Cerberus Fossae, which is located more than 1,000 kilometers away from the lander.

The surface of Cerberus Fossae is notorious for being broken up and experiencing periodic rockfalls. According to geophysicist Philippe Lognonné, who is the lead investigator of the Seismic Experiment for Interior Structure, the seismometer that is onboard the InSight lander, it is reasonable to assume that the ground is moving in that area. "This is an old crater from a volcanic eruption."

Marsquakes, which are similar to earthquakes in that they give information about the interior structure of our planet, can be utilized to investigate what lies beneath the surface of Mars (SN: 7/22/21). And according to Lognonné, who works at the Institut de Physique du Globe in Paris, there is a great deal that can be gleaned from analyzing this massive earthquake. Because the quality of the signal is so high, we will be able to focus on the specifics.